IndraLab

Statements

USP11 inhibits viral RNA replication. 5 / 5
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"In addition , USP11 also can interact with viral PB2 and PA protein , thereby inhibiting viral RNA replication ."
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"USP11 inhibits viral RNA replication through deubiquitinating on K184 of NP ."
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"This result further supports the conclusion that USP11 inhibits viral RNA replication through deubiquitinating NP ."
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"These results combined suggest that USP11 inhibits viral RNA replication through deubiquitinating NP ."
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"When cellular USP11 was knocked down , the amounts of vRNA and cRNA of the wild-type virus increased by about 2.5-fold ( Figure 7A , lane 1 versus lanes 2 and 3 ) , indicating that USP11 inhibits viral RNA replication as previously mentioned ; with the mutant virus defective in NP ubiquitination ( K184R ) , however , there was no significant difference in viral RNA synthesis between USP11 knockdown and control cells ( Figure 7A , lanes 4-6 ) ."
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