IndraLab

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UCHL1 increases the amount of CDKN1A. 4 / 4
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"However, in the presence of MG132, PDGF-BB was still able to upregulate p21 WAF1 and Cip1 protein levels while overexpression of UCH-L1 enhanced not only the PDGF-BB-induced upregulation of p21 WAF1 and Cip1 protein in presence of MG132 but also the basal increased p21 WAF1 and Cip1 protein level induced by MG132 per se (XREF_FIG, XREF_SUPPLEMENTARY)."
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"We further found that UCHL1 induced p53 accumulation and reduced MDM2 protein level, and subsequently upregulated the expression of p21, as well as cleavage of caspase3 and PARP, but not in catalytic mutant UCHL1 C90S expressed cells."
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"Taken together, these findings demonstrate that UCH-L1 potentiates PDGF-BB-induced upregulation of p21 WAF1 and Cip1 protein expression via suppressing autophagic protein clearance in cardiac fibroblasts."
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"These results suggest that UCH-L1 enhance PDGF-BB-induced p21 WAF1 and Cip1 protein expression via suppressing autophagy activation by increasing mTOR activity."
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