IndraLab

Statements

USP14 inhibits HMBS. 3 / 3
| 1 2
eidos
"13 IU1 , an inhibitor of USP14 , can increase UPS activities , promote Tau degradation , and enhance mitochondrial elimination in neuronal cells.14 , 15 , 16 Similarly , dysregulation of USP14 has been reported in several tumors , including breast cancer , lung adenocarcinoma , and epithelial ovarian cancer.17 , 18 , 19 However , whether USP14 is involved in preeclampsia remains elusive ."
34089575
reach
"Taken together, these data show that phosphorylation of USP14 by Akt is important for this kinase to negatively regulate the UPS in a ubiquitin dependent manner."
26523394
reach
"Interestingly, it appears USP14 not only negatively regulates the UPS, but also negatively regulates autophagy through removing Lys63 linked ubiquitin chains from the autophagy regulator Beclin-1 [XREF_BIBR]."
33414510