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EGF phosphorylates EGFR on Y1092. 74 / 76
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"PKG II Blocks EGF-induced Tyr 992 and Tyr 1068 Phosphorylation of EGFR."
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"Therefore, we examined whether SPE could inhibit EGF-induced EGFR phosphorylation at Tyr-1068."
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"PKG II inhibited EGF-induced migration activity and blocked EGF-initiated signal transduction of PLCγ1 and MAPK/ERK-mediated pathways through preventing EGF-induced Tyr 992 and Tyr 1068 phosphorylation of EGFR."
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"Moreover, labeling with a phospho specific antibody showed that EGF-SEA probably caused EGFR phosphorylation at Tyr 1068 (XREF_FIG)."
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"First, we examined EGF-induced phosphorylation of EGFR tyrosine 1068 (p-EGFR)."
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"EGF was unable to induce EGFR phosphorylation at Tyr845 but marginally induced the EGFR phosphorylation at Tyr1068 in pCMV-SrcK295R-transfected cells."
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"We found that MUC20 overexpression increased EGF triggered phosphorylation of EGFR and Y845, EGFR and Y1068, Src, and STAT3."
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"We investigated the phosphorylation status of EGFR in differentiating NSCs, and found that Chi3l3 and its canonical ligand EGF significantly induced phosphorylation of the EGFR at tyrosine 1068 after 15 min (Fig.  xref )."
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"A further difference could be observed in the induction of phosphorylated Egfr Y1068 and Egfr Y1092 by EGF, which is absent in the case of TGF-beta1 treatment."
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"Amos et al. [41] also reported that EGF treatment causes EGFR phosphorylation at Tyr1068 and Tyr845 in glioblastoma cells."
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"The EGF-induced EGFR phosphorylation at Y1068 was improved by C1GALT1 overexpression, and HNSCC cell invasion, migration and activity was also improved ( xref )."
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"In BRAF WT/EGFR expressing SK-MEL147 cells, EGF stimulated the phosphorylation of EGFR at Tyr1068, erbB2 at Tyr1248, erbB3 at Tyr1328, and erbB4 at Tyr1056, whereas NRG1 induced the phosphorylation of EGFR, erbB3, and erbB4 (XREF_FIG)."
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"Meanwhile, MSI2 silencing inhibited EGF enhanced EGFR phosphorylation at tyrosine 1068 and reversed EGF induced change of the key proteins in EMT and ZEB1-ERK and MAPK signaling (ZEB1, E-cad, ZO-1, beta-catenin, pERK and c-Myc)."
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"In contrast, EGF stimulation of ECC-1 cells caused tyrosine phosphorylation of EGFR (Y1068), activation of the downstream target ERK, and subsequent EGFR downregulation."
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"Brefelamide diminished the EGF-induced phosphorylation of the EGF receptor at Tyr 1068 , leading to an inhibition of the Ras/Raf/ERK system."
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"In this study, overexpression of MUC20 increased EGF triggered phosphorylation of EGFR at Y845 and Y1068 and also enhanced phosphorylation of STAT3, but not ERK1/2 and AKT."
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"However, in HER2 YVMA -expressing cells, EGF only modestly increased the high basal P-HER2 and EGFR phosphorylation at Y1068 and Y845."
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"EGF also markedly and immediately induced the phosphorylation of EGFR at Tyr1045 and Tyr1068 at 0.5 min, reached a maximum within 1 min (data not shown), continued for up to 60 min, and decreased at 120 min after EGF-treatment."
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"Interestingly, we also observed that EGF treatment elicited robust phosphorylations of both EGFR at Y1068 and ERK, even in cells knocked down for ROR1."
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"The EGF-induced heteromultimer is phosphorylated at EGFR Y1068, corresponding to EGFR kinase activity, and EphA2 S897, corresponding to kinase activation and the availability of EphA2 as a substrate for serine/threonine kinases (63)."
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"As shown in Fig. 4 A, EGF treatment induced EGFR phosphorylation at Tyr845 and Tyr1068 and an increase in Src activation (Tyr416 phosphorylation)."
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"EGF stimulation led to a robust phosphorylation of the EGFR on Y1045 and Y1068, the docking sites of c-Cbl and Grb2, respectively, in the controls, but phosphorylation on these sites was significantly reduced in the HER2 cells (XREF_FIG)."
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"These deficiencies of formalin are more than tissue based penetration related issues as we have shown that formalin failed to preserve an EGF induced increase in the phosphorylation of EGFR Tyr1068 in suspension cells that are likely immediately fixed, thus indicating inadequate retention of phosphorylation due to the slow inhibition of phosphatase enzymes (XREF_FIG)."
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"This further suggests that loss of CD81, which substantially reduces EGF binding, may not impact EGF-stimulated EGFR Y1068 phosphorylation because of enhanced contribution of EGFR oligomerization to signaling upon CD81 silencing."
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"Both HCMV and EGF induced EGFR phosphorylation at Tyr residue 1068."
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"As shown in xref ( left) , EGF-induced EGFR phosphorylation at Tyr1068 site was largely inhibited by the combined treatments, whereas no significant change of EGFR activation was observed in SGC-7901 cells treated with single agent alone."
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"In BRAF WT/EGFR expressing SK-MEL147 cells, EGF stimulated the phosphorylation of EGFR at Tyr1068, erbB2 at Tyr1248, erbB3 at Tyr1328, and erbB4 at Tyr1056, whereas NRG1 induced the phosphorylation of EGFR, erbB3, and erbB4 ( xref )."
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"In contrast, overexpression of PTP μ decreased EGF-stimulated EGFR Y992 and Y1068 phosphorylation."
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"Moreover, it has been reported that one juxtamembrane region in the EGFR family members present a putative nuclear localization sequence, which mediates the localization of EGFR in the nucleus (14) an[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"HRG-beta1 mainly increased the phosphorylation of ERBB2 (Y1121/1122) and ERBB3 (Y1289) as well as AKT (S473) and ERK1/2, whereas EGF induced the phosphorylation of EGFR (Y1068), ERBB2 (Y1121/1122) and ERK1/2."
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"EGF produced a rapid (15 min) and transient increase in tyrosine phosphorylation of EGFR, most notable at Y1068 and Y845."
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"Our findings also demonstrate that EGF induces an increase in the phosphorylation of EGFR at Tyr 1068 and the EGFR and DNA complex formation."
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"EGF increased EGFR phosphorylation at Tyr 1068, and pretreatment with 3% SPE significantly suppressed EGFR phosphorylation, as well as ERK activation (XREF_FIG B)."
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"We next investigated the correlation between ROCK and EGF signaling, and found that exposure to Y27632 or knockdown of ROCK using siRNA strengthened the EGF-induced phosphorylation of EGFR at Tyr1045 and Tyr1068 (Figure xref )."
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"In contrast, EGF stimulation in CL1 cells did elicit phosphorylation of EGFR (Y1068)."
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"First, we found that EGF can increase EGFR Y1068 phosphorylation and activate STAT1/3/5, c-Jun N-terminal kinase (JNK), p38, and extracellular signal-regulated kinases (ERK) in NHEK and HaCaT cells ( [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Increased Akt and rpS6 phosphorylation were observed in the CL 1-5 cells under the dcEF stimulation in the serum containing medium, in agreement with the results in the RTK assay described in section F. EGF stimulated CL 1-5 cells show significant EGFR (Tyr1068) phosphorylation compared to the control group, while neither CL 1-5 cells nor CL1-0 cells show EGFR Tyr1068 phosphorylation under the dcEF stimulation."
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"EGF induced the phosphorylation of tyrosine-1068 of the EGFR, and this phosphorylation was suppressed by OMD expression ( xref b)."
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"As expected, EGF incubation greatly increased phosphorylation of EGFR (Tyr 1068, Tyr 1086, Tyr 845) and extracellular signal-regulated kinase (ERK), but not JAK, Src or STATs."
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"We next examined the effect of siRNA gene silencing of CHC on EGF-stimulated EGFR Y1068 phosphorylation."
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"This indicated that PKG II could prevent EGF-induced Tyrosine 992 and Tyrosine 1068 phosphorylation of EGFR and consequently inhibit PLCγ1-mediated and MAPK/ERK–mediated signaling."
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"EGF treatment of CIP4 CON and KD cells led to rapid phosphorylation of EGFR (pEGFR; Y1068) that was sustained throughout the time course."
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"PKG II inhibits EGF-induced tyrosine 1068 phosphorylation of EGFR and its downstream pathways."
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"EGF abundantly stimulated EGFR phosphorylation at Tyr992, Tyr1045, and Tyr1068, whereas amphiregulin did not stimulate phosphorylation at Tyr992 in either the NHBE or the BSMC."
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"Moreover, the EGF-induced EGFR phosphorylation at Tyr845 and Tyr1068 was reduced in pCMV-SrcK295R-transfected cells, when compared to vector-transfected control cells."
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"However, when we repeated this experiment in cells overexpressing the Q8A and Q408A EGFR variants, PCB126 did not affect the EGF-induced phosphorylation of EGFR Y1068 ( xref )."
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"We observed a decrease in EGF-induced EGFR phosphorylation at Tyr-845 and/or Tyr-1068 residue(s) in the presence of AnxA2 antibody, suggesting that AnxA2 regulates the overall function of EGFR, leading to the inhibition of cancer cell proliferation and migration."
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"The reduced ability of EGF to stimulate EGFR phosphorylation at Y1068 was observed shortly after PDT and lasted for at least 2 h, but resumed 24 h after light exposure."
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"In contrast, galardin did not inhibit EGF-induced EGFR Tyr-845 and Tyr-1068 phosphorylation ( Fig. 2 inserts), indicating that MMP-mediated phosphorylation of these sites is specific to GPCR signalin[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Our data showed that B4GALNT3 knockdown suppressed EGF-induced phosphorylation of EGFR at Y845 and Y1068 (Figure xref )."
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"Tephrosin decreased EGF-induced phosphorylation of EGFR at Tyr1068, and ErbB2 at Tyr877 in a dose-dependent manner."
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"This is consistent with the formation of EGFR oligomers at low [EGF] that together with clathrin nanodomains contribute to confinement of ligand-bound EGFR.This further suggests that loss of CD81, which substantially reduces EGF binding, may not impact EGF-stimulated EGFR Y1068 phosphorylation because of enhanced contribution of EGFR oligomerization to signaling upon CD81 silencing."
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"EGF-stimulated S365 BRAF dephosphorylation, MEK, ERK, and RSK phosphorylation, but not AKT and EGFR Y1068 phosphorylation, were severely impaired in SHOC2 knockdown (KD) cells, consistent with a selective role of SHOC2 in RAF-ERK pathway activation (Fig. 2A)."
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"EFEMP1 has been shown to bind EGFR in a competitive manner relative to EGF to phosphorylate EGFR at Tyr-992 and Tyr-1068 positions for activation of AKT [20] ."
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"Interestingly, extracellular EGF did not significantly increase phosphorylation of the EGFR (Tyr1068) and only slightly increased c-Src phosphorylation, which indicates almost maximal autocrine stimul[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"This indicated that PKG II could prevent EGF induced Tyrosine 992 and Tyrosine 1068 phosphorylation of EGFR and consequently inhibit PLCgamma1 mediated and MAPK and ERK mediated signaling."
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"As expected, we found that the EGF induced ATMCs displayed an active phosphorylation of the EGF receptor (Tyr1068) and of its downstream signalling pathways molecules AKT and ERK1/2 (XREF_FIG)."
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"Accordingly, although EGF led to phosphorylation of the EGFR at Tyr1068, no phosphorylation at this residue was observed in BEAS-2B exposed to PsaDM (XREF_FIG)."
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"However, in HER2-expressing cells, EGF only modestly increased the high basal P-HER2 and EGFR phosphorylation at Y1068 and Y845 (B)."
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"However, pre-treatment with ECG or EGCG dimer inhibited EGF-induced Tyr 1068 EGFR phosphorylation in lipid rafts."
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"In contrast, overexpression of PTPmu decreased EGF stimulated EGFR Y992 and Y1068 phosphorylation."
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"Our previous results showed that PKG II could inhibit EGF-induced tyrosine 1068 phosphorylation of EGFR in gastric cancer cell line BGC-823 xref , raising the question whether PKG II can inhibit the phosphorylation of other tyrosine sites on EGF/EGFR and thereafter have a wide-range inhibition on EGF/EGFR-induced signal transductions and related biological activities of gastric cancer cells."
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"We next examined the effects of Y27632 on the EGF-induced phosphorylation of EGFR at Tyr1045 and Tyr1068 in Panc1, KP3 and AsPc1 cells."
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"EGF abundantly stimulated EGFR phosphorylation at Tyr992, Tyr1045, and Tyr1068, whereas amphiregulin did not stimulate phosphorylation at Tyr992 in either the NHBE or the BSMC."
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"EGF (20 ng/ml) also increased tyrosine phosphorylation of the EGF receptor (Tyr 1068), as expected."
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"In order to test this hypothesis, phosphorylation of the EGF receptor at tyrosine-1068 by EGF was tested for after exposure to singlet oxygen (Fig. 6A) or C2-ceramide (Fig. 6B)."
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"It also decreased EGF-stimulated EGFR phosphorylation at Y1068, which likely indicates inactivation of EGFR/ErbB3 dimers."
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"Elevated FAM83B expression resulted in increased EGF-stimulated EGFR-Y1068 phosphorylation at the 15, 30 and 120 minute time points, further supporting a role for FAM83B in EGFR activation ( xref )."
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"PP1 cause only minor reduction of EGF induced EGFR phosphorylation at Y1068."
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"As expected, EGF treatment of H1299 V and KD cells led to rapid phosphorylation of EGFR (pEGFR; Y1068) that was sustained throughout the time course (XREF_FIG)."
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"First, we found that EGF can increase EGFR Y1068 phosphorylation and activate STAT1/3/5, c-Jun N-terminal kinase (JNK), p38, and extracellular signal regulated kinases (ERK) in NHEK and HaCaT cells."
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"GALNT8 inhibits the EGF-induced phosphorylation of EGFR at Y1068 and suppresses breast cancer metastasis by regulating the EMT process."
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"Silencing of CD81 does not alter EGF-stimulated EGFR phosphorylation at Y1068, Y1173, and Y845, nor phosphorylation of Akt and Erk that depend on EGFR Y1068 and/or Y1173 phosphorylation (Fig. 7A, B)."
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"Moreover, labeling with a phospho-specific antibody showed that EGF-SEA probably caused EGFR phosphorylation at Tyr-1068 ( xref )."
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