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EGF phosphorylates EGFR on Y1092. 54 / 54
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"HRG-beta1 mainly increased the phosphorylation of ERBB2 (Y1121/1122) and ERBB3 (Y1289) as well as AKT (S473) and ERK1/2, whereas EGF induced the phosphorylation of EGFR (Y1068), ERBB2 (Y1121/1122) and ERK1/2."
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"In contrast, overexpression of PTP μ decreased EGF-stimulated EGFR Y992 and Y1068 phosphorylation."
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"In contrast, overexpression of PTPmu decreased EGF stimulated EGFR Y992 and Y1068 phosphorylation."
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"EGF induced the phosphorylation of tyrosine-1068 of the EGFR, and this phosphorylation was suppressed by OMD expression ( xref b)."
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"We observed a decrease in EGF-induced EGFR phosphorylation at Tyr-845 and/or Tyr-1068 residue(s) in the presence of AnxA2 antibody, suggesting that AnxA2 regulates the overall function of EGFR, leading to the inhibition of cancer cell proliferation and migration."
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"This indicated that PKG II could prevent EGF induced Tyrosine 992 and Tyrosine 1068 phosphorylation of EGFR and consequently inhibit PLCgamma1 mediated and MAPK and ERK mediated signaling."
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"These deficiencies of formalin are more than tissue based penetration related issues as we have shown that formalin failed to preserve an EGF induced increase in the phosphorylation of EGFR Tyr1068 in suspension cells that are likely immediately fixed, thus indicating inadequate retention of phosphorylation due to the slow inhibition of phosphatase enzymes (XREF_FIG)."
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"PP1 cause only minor reduction of EGF induced EGFR phosphorylation at Y1068."
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"This indicated that PKG II could prevent EGF-induced Tyrosine 992 and Tyrosine 1068 phosphorylation of EGFR and consequently inhibit PLCγ1-mediated and MAPK/ERK–mediated signaling."
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"Moreover, labeling with a phospho-specific antibody showed that EGF-SEA probably caused EGFR phosphorylation at Tyr-1068 ( xref )."
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"Meanwhile, MSI2 silencing inhibited EGF enhanced EGFR phosphorylation at tyrosine 1068 and reversed EGF induced change of the key proteins in EMT and ZEB1-ERK and MAPK signaling (ZEB1, E-cad, ZO-1, beta-catenin, pERK and c-Myc)."
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"PKG II Blocks EGF-induced Tyr 992 and Tyr 1068 Phosphorylation of EGFR."
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"Our findings also demonstrate that EGF induces an increase in the phosphorylation of EGFR at Tyr 1068 and the EGFR and DNA complex formation."
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"Increased Akt and rpS6 phosphorylation were observed in the CL 1-5 cells under the dcEF stimulation in the serum containing medium, in agreement with the results in the RTK assay described in section F. EGF stimulated CL 1-5 cells show significant EGFR (Tyr1068) phosphorylation compared to the control group, while neither CL 1-5 cells nor CL1-0 cells show EGFR Tyr1068 phosphorylation under the dcEF stimulation."
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"EGF abundantly stimulated EGFR phosphorylation at Tyr992, Tyr1045, and Tyr1068, whereas amphiregulin did not stimulate phosphorylation at Tyr992 in either the NHBE or the BSMC."
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"Therefore, we examined whether SPE could inhibit EGF-induced EGFR phosphorylation at Tyr-1068."
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"As expected, EGF treatment of H1299 V and KD cells led to rapid phosphorylation of EGFR (pEGFR; Y1068) that was sustained throughout the time course (XREF_FIG)."
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"Elevated FAM83B expression resulted in increased EGF-stimulated EGFR-Y1068 phosphorylation at the 15, 30 and 120 minute time points, further supporting a role for FAM83B in EGFR activation ( xref )."
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"Moreover, labeling with a phospho specific antibody showed that EGF-SEA probably caused EGFR phosphorylation at Tyr 1068 (XREF_FIG)."
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"However, when we repeated this experiment in cells overexpressing the Q8A and Q408A EGFR variants, PCB126 did not affect the EGF-induced phosphorylation of EGFR Y1068 ( xref )."
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"PKG II inhibits EGF-induced tyrosine 1068 phosphorylation of EGFR and its downstream pathways."
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"Interestingly, we also observed that EGF treatment elicited robust phosphorylations of both EGFR at Y1068 and ERK, even in cells knocked down for ROR1."
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"However, in HER2-expressing cells, EGF only modestly increased the high basal P-HER2 and EGFR phosphorylation at Y1068 and Y845 (B)."
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"In BRAF WT/EGFR expressing SK-MEL147 cells, EGF stimulated the phosphorylation of EGFR at Tyr1068, erbB2 at Tyr1248, erbB3 at Tyr1328, and erbB4 at Tyr1056, whereas NRG1 induced the phosphorylation of EGFR, erbB3, and erbB4 (XREF_FIG)."
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"Our data showed that B4GALNT3 knockdown suppressed EGF-induced phosphorylation of EGFR at Y845 and Y1068 (Figure xref )."
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"EGF treatment of CIP4 CON and KD cells led to rapid phosphorylation of EGFR (pEGFR; Y1068) that was sustained throughout the time course."
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"Accordingly, although EGF led to phosphorylation of the EGFR at Tyr1068, no phosphorylation at this residue was observed in BEAS-2B exposed to PsaDM (XREF_FIG)."
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"EGF produced a rapid (15 min) and transient increase in tyrosine phosphorylation of EGFR, most notable at Y1068 and Y845."
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"Moreover, it has been reported that one juxtamembrane region in the EGFR family members present a putative nuclear localization sequence, which mediates the localization of EGFR in the nucleus (14) an[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In this study, overexpression of MUC20 increased EGF triggered phosphorylation of EGFR at Y845 and Y1068 and also enhanced phosphorylation of STAT3, but not ERK1/2 and AKT."
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"EGF stimulation led to a robust phosphorylation of the EGFR on Y1045 and Y1068, the docking sites of c-Cbl and Grb2, respectively, in the controls, but phosphorylation on these sites was significantly reduced in the HER2 cells (XREF_FIG)."
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"In contrast, galardin did not inhibit EGF-induced EGFR Tyr-845 and Tyr-1068 phosphorylation ( Fig. 2 inserts), indicating that MMP-mediated phosphorylation of these sites is specific to GPCR signalin[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"We investigated the phosphorylation status of EGFR in differentiating NSCs, and found that Chi3l3 and its canonical ligand EGF significantly induced phosphorylation of the EGFR at tyrosine 1068 after 15 min (Fig.  xref )."
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"First, we found that EGF can increase EGFR Y1068 phosphorylation and activate STAT1/3/5, c-Jun N-terminal kinase (JNK), p38, and extracellular signal regulated kinases (ERK) in NHEK and HaCaT cells."
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"EGF induces the nuclear accumulation of EGFR, an increase in EGFR phosphorylation at Tyr 1068 and the formation of the complex EGFR and DNA in MCF-7 and MDA-MB-231 breast cancer cells."
19766894
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"EGF abundantly stimulated EGFR phosphorylation at Tyr992, Tyr1045, and Tyr1068, whereas amphiregulin did not stimulate phosphorylation at Tyr992 in either the NHBE or the BSMC."
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"A further difference could be observed in the induction of phosphorylated Egfr Y1068 and Egfr Y1092 by EGF, which is absent in the case of TGF-beta1 treatment."
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"As expected, we found that the EGF induced ATMCs displayed an active phosphorylation of the EGF receptor (Tyr1068) and of its downstream signalling pathways molecules AKT and ERK1/2 (XREF_FIG)."
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"We next examined the effects of Y27632 on the EGF-induced phosphorylation of EGFR at Tyr1045 and Tyr1068 in Panc1, KP3 and AsPc1 cells."
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"However, in HER2 YVMA -expressing cells, EGF only modestly increased the high basal P-HER2 and EGFR phosphorylation at Y1068 and Y845."
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"We next examined the effect of siRNA gene silencing of CHC on EGF-stimulated EGFR Y1068 phosphorylation."
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"In contrast, EGF stimulation in CL1 cells did elicit phosphorylation of EGFR (Y1068)."
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"Our previous results showed that PKG II could inhibit EGF-induced tyrosine 1068 phosphorylation of EGFR in gastric cancer cell line BGC-823 xref , raising the question whether PKG II can inhibit the phosphorylation of other tyrosine sites on EGF/EGFR and thereafter have a wide-range inhibition on EGF/EGFR-induced signal transductions and related biological activities of gastric cancer cells."
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"EGF (20 ng/ml) also increased tyrosine phosphorylation of the EGF receptor (Tyr 1068), as expected."
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"PKG II inhibited EGF-induced migration activity and blocked EGF-initiated signal transduction of PLCγ1 and MAPK/ERK-mediated pathways through preventing EGF-induced Tyr 992 and Tyr 1068 phosphorylation of EGFR."
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"As shown in xref ( left) , EGF-induced EGFR phosphorylation at Tyr1068 site was largely inhibited by the combined treatments, whereas no significant change of EGFR activation was observed in SGC-7901 cells treated with single agent alone."
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"EGF also markedly and immediately induced the phosphorylation of EGFR at Tyr1045 and Tyr1068 at 0.5 min, reached a maximum within 1 min (data not shown), continued for up to 60 min, and decreased at 120 min after EGF-treatment."
21722395
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"First, we found that EGF can increase EGFR Y1068 phosphorylation and activate STAT1/3/5, c-Jun N-terminal kinase (JNK), p38, and extracellular signal-regulated kinases (ERK) in NHEK and HaCaT cells ( [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
30197274
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"In BRAF WT/EGFR expressing SK-MEL147 cells, EGF stimulated the phosphorylation of EGFR at Tyr1068, erbB2 at Tyr1248, erbB3 at Tyr1328, and erbB4 at Tyr1056, whereas NRG1 induced the phosphorylation of EGFR, erbB3, and erbB4 ( xref )."
24709886
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"We next investigated the correlation between ROCK and EGF signaling, and found that exposure to Y27632 or knockdown of ROCK using siRNA strengthened the EGF-induced phosphorylation of EGFR at Tyr1045 and Tyr1068 (Figure xref )."
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"We found that MUC20 overexpression increased EGF triggered phosphorylation of EGFR and Y845, EGFR and Y1068, Src, and STAT3."
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"In contrast, EGF stimulation of ECC-1 cells caused tyrosine phosphorylation of EGFR (Y1068), activation of the downstream target ERK, and subsequent EGFR downregulation."
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"EGF increased EGFR phosphorylation at Tyr 1068, and pretreatment with 3% SPE significantly suppressed EGFR phosphorylation, as well as ERK activation (XREF_FIG B)."
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"However, pre-treatment with ECG or EGCG dimer inhibited EGF-induced Tyr 1068 EGFR phosphorylation in lipid rafts."
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