IndraLab

Statements

MAPK1 activates RPS6KA1. 6 / 16
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"Nonetheless, the results of XREF_FIG suggest that manipulation of mTORC1 signaling by KSHV is being effected through the release from inhibition by TSC2 that is induced by ERK2 mediated activation of RSK1."
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"All assays showed that ERK2 activated RSK1, while p38 activated MK2 ( xref )."
32649858
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"During this " dysregulated lytic program ", expression of KSHV ORF45 leads to selective activation of mTORC1 by ERK2 mediated activation of RSK1, which sensitizes these LECs to rapamycin induced killing."
25514370
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"In this context, sulfenylation of ERK2 increases RSK1 kinase activity [94]."
38247507
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"Finally in the case of MAPK/ERK to TOR cross-talk, facilitated by the activation of RPS6KA1 by MAPK1 in the mouse, we found orthologues in both other organisms but no interaction in the fly."
25064569
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"Finally in the case of MAPK and ERK to TOR cross-talk, facilitated by the activation of RPS6KA1 by MAPK1 in the mouse, we found orthologues in both other organisms but no interaction in the fly."
25064569