IndraLab

Statements

KCNA3 binds mgt. 4 / 4
| 4
sparser
"We construct the potential of mean force (PMF) profile of the binding of the MgTx-Kv1.3 complex predicted from our simulations."
25054783
sparser
"Acetylation or biotinylation of the amino group reduced binding (10-fold) of MgTX to Kv1.3, suggesting the involvement of the N-terminal amino group in the toxin activity [30] ."
9395089
sparser
"We examine the binding of MgTx to Kv1.3 using molecular dynamics with distance restraint."
25054783
sparser
"The simulations suggest that MgTx-Lys35 occludes the ion conduction pathway of the channel on the formation of the MgTx-Kv1.3 complex, while Lys28 of the toxin stabilizes the complex by forming an additional salt bridge with Asp449, located just outside of the selectivity filter."
25054783