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Electrophilic reagent inhibits UCHL3. 1 / 1

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"These endogenous electrophiles (1) inhibit ubiquitin isopeptidase activity [ xref ] as well as ubiquitin hydrolases UCH-L1 and UCH-L3 [ xref ], (2) induce the formation of cysteine-targeted thyolation of UCH-L1 [ xref ] and of PGJ2/proteasome conjugates [ xref ], (3) trigger the oxidation of the S6 ATPase subunit of the 26S proteasome [ xref ], and disrupt 26S proteasome assembly [ xref ]."

19630993

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IndraLab

Statements

Electrophilic reagent inhibits UCHL3. 1 / 1

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