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COPS5 inhibits Cyclin_E. 5 / 5
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"For example, Doronkin et al. demonstrated that depletion of Jab1 and COPS5 induced cyclin E stability whereas Jab1 and COPS5 overexpression rapidly degraded cyclin E."
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"These features offer a valuable model for studying the role of cell divisions in cellular differentiation and patterning in a defined lineage.In this paper, we report that CSN5 and CSN mediates SCF de[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"For example, Jab1/CSN5 depletion increased cyclin E stability whereas Jab1/CSN5 overexpression stimulated rapid cyclin E degradation ( Doronkin et al., 2003 )."
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"We conclude that CSN5 stimulates Cyclin E degradation.We also overexpressed Cyclin E in wild-type flies to determine its effects on oogenesis when the CSN was not mutant."
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"Our results show that the CSN regulates the turnover of Cyclin E. Decreased expression of CSN5 increased Cyclin E stability, and increased CSN5 expression stimulated rapid Cyclin E degradation."
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