IndraLab

Statements

ZUP1 activates Interferon. 5 / 5
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"For example, the DUB enzyme cylindromatosis (CYLD) was shown to directly bind RIG-I and mediate the removal of K63-ub and limit IFN induction [45]."
21949557
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"Here we characterized the DUB and IFN antagonism activities of the PLP domains of human coronavirus NL63 and severe acute respiratory syndrome (SARS) coronavirus to determine if DUB activity mediates interferon antagonism."
20181693
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"For instance, above-mentioned studies found the distantly related HCoV-NL63 and SARS-CoV to be similar in essential features such as protease-independent, DUB-mediated IFN antagonism, while the MERS-CoV that is much closer related to SARS-CoV only inhibits IFN induction when the protease function is intact (e.g., [34, 37])."
30248143
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"The blocking of induction of IFN by DUB activity was also confirmed for MERS-CoV, but in contrast to SARS-CoV, this inhibition is not independent of PLP’s protease activity [40, 41]."
30248143
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"We further 223 investigated the differences in the interferon response generated in response to WT versus 224 DUBmut virus in our companion study (Volk et al., submitted) , which further supports a role for 225 DUB activity in modulating the interferon response in macrophages.The structure-guided approach used to generate the DUBmut virus allowed for substitution."
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