IndraLab

Statements

CYLD ubiquitinates TBK1. 4 / 4
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"NEDD4 and CYLD were validated to catalyze ploy-ubiquitination of TBK1 and negatively regulate type I IFN signaling (32, 33) , while CYLD was observed to remove Lys 63-linked polyubiquitin from TBK1 (33) ."
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"CYLD was initially thought to inhibit IFN signaling by deubiquitinating the PRR, RIG1, and downstream kinases TBK-1 and IKKepsilon 44, but surprisingly, IFN response to vesicular stomatitis virus in CYLD knockout mice or cells from these mice was abrogated 45."
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"We further show that CYLD targets a cytoplasmic RNA sensor, RIG-I, and inhibits the ubiquitination of this IKKepsilon and TBK1 stimulator."
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"It was initially believed that CYLD inhibited IFN signaling by deubiquitinating the PRR, RIG-1, and downstream kinases TANK binding kinase 1 (TBK-1) and inhibitor of NF-kappaB kinase Epsilon (IKKEpsilon) 44; but, surprisingly, IFN response to vesicular stomatitis virus in CYLD knockout mice or cells from these mice was abrogated.45 On the basis of these reports, TRAF3 and CYLD may serve similar functions after viral infection, namely, to inhibit NF-kappaB and activate IFN."
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