IndraLab

Statements

AR is palmitoylated. 30 / 30
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"These data indicate that the mutation on β 2 AR palmitoylation site at C341 selectively reduces receptor association with PDE4 without globally disrupting association with AKAP and adenylate cyclase."
22912718
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"We used two complimentary strategies to examine the functional implication of palmitoylation of β 2 AR in cardiomyocytes."
22912718
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"Here we describe S -palmitoylation of the β 3 AR."
30541923
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"Here, we demonstrate that in cardiomyocytes, palmitoylation of β 2 AR, the covalent acylation of cysteine residue 341, plays a critical role in shaping subcellular cAMP-PKA activities in cardiomyocytes via regulating β 2 AR association with arrestin/PDE4D. Replacing cysteine 341 on β 2 AR with alanine (C341A) leads to an impaired binding to β arrestin 2."
22912718
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"A(1)AR palmitoylation is abolished by treatment with neutral hydroxylamine or by mutation of Cys-309 to Ala (C(309)-->A)."
10455026
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"However, site-directed mutagenesis of this residue has not been performed for any AR subtype, and no role for putative AR palmitoylation has been described."
10722120
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"Early studies suggest that the palmitoylation of β 2 AR reduces the receptor coupling to Gs proteins for activation of adenylate cyclase and PKA phosphorylation of receptor in Chinese hamster fibroblasts xref , the functional implication remains unclear."
22912718
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"Disruption of Palmitoylation of β 2 AR Reduces Recruitment of Arrestin to the Phosphorylated Receptor Under Agonist Stimulation."
22912718
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"A(1)AR palmitoylation is abolished by treatment with neutral hydroxylamine or by mutation of Cys-309 to Ala (C(309)-->A)."
10455026
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"Specifically, we like to examine whether palmitoylation of β 2 AR affects agonist-induced receptor trafficking and receptor association with other effectors like PDE4D isoforms in signaling complex."
22912718
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"Disruption of Palmitoylation of β 2 AR Alters Agonist-induced Receptor Internalization Pathway."
22912718
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"Disruption of Palmitoylation of β 2 AR Enhances Agonist-induced cAMP-PKA Activation in the Cytoplasm and Myocyte Contraction Response."
22912718
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"There are no previous reports regarding palmitoylation of α1D AR, however, the α1B AR was found to be palmitoylated at two cysteines in the C terminal tail in a ligand dependent fashion xref ."
26715683
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"Second, palmitoylation of β 2 AR modulate the receptor endocytic pathways under agonist stimulation."
22912718
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"Previous study on β 2 AR palmitoylation in Chinese hamster fibroblasts suggests that mutation of the palmitoylation residue reduces β 2 AR/Gs coupling to activate adenylate cyclases for cAMP production on the isolated plasma membrane xref ."
22912718
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"Losing β 2 AR palmitoylation leads to higher basal cAMP-PKA activity."
22912718
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"Disruption of Palmitoylation of β 2 AR Reduces Receptor Association with PDE4D Isoforms at Both Resting and Stimulating Conditions."
22912718
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"Palmitoylation of the α1B AR has been reported at such a position xref ."
26715683
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"We used the palmitoylation inhibitor 2-bromopalmitate (Sigma Aldrich) to inhibit palmitoylation of AR."
28642789
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"In comparison, the role of β 2 AR palmitoylation and its effects on receptor signaling and function in cardiomyocytes remain to be addressed."
22912718
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"In the present study, we reveal a couple of new functional properties of palmitoylation of β 2 AR in function and signaling."
22912718
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"In this context, we hypothesize that palmitoylation of β 2 AR affects the receptor signaling and function in cardiomyocytes."
22912718
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"Together, we have shown that palmitoylation of β 2 AR modulates receptor signaling in cardiomyocytes via regulating the receptor-associated complexes."
22912718
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"In conclusion, our data indicate that palmitoylation of β 2 AR is required for receptor association with arrestin-PDE4Ds to shape subcellular cAMP level in cardiomyocytes for contraction response."
22912718
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"From DHHC-7 and -21 knockdown studies, the PATs are required for endogenous ER, PR, and AR palmitoylation, membrane trafficking, and rapid signal transduction in cancer cells."
22031296
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"As seen in xref and quantified in xref , palmitoylation of α1D AR (myc tagged) was increased ~2.5 fold in the presence of WT ZDHHC21 (HA-tagged), but not when co-expressed with either ZDHHC21 F233Δ or a mutant in which the key catalytic cysteine is mutated to serine (C120S)."
26715683
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"Knockdown of DHHC-7 or -21 with siRNA diminished AR localization only at the PM ( xref ) and diminished AR palmitoylation ( xref )."
22031296
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"Disruption of palmitoylation of β 2 AR selectively abolishes the receptor interaction with β arrestin 2 and PDE4D enzymes for cAMP degradation without affecting the receptor association with AKAP and adenylate cyclase."
22912718
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"Thus, we set out to study how β 2 AR palmitoylation influences receptor signaling pathway in cardiomyocytes."
22912718
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"Disruption of Palmitoylation of β 2 AR Alters Spatio-temporal Distribution of Agonist-induced cAMP in Cardiomyocytes."
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