IndraLab

Statements

AR is palmitoylated. 22 / 22
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"The Sf9 cell system also led to a better understanding of the interactions between palmitoylation and phosphorylation of the β 2 AR."
20705094
sparser
"We used the palmitoylation inhibitor 2-bromopalmitate (Sigma Aldrich) to inhibit palmitoylation of AR."
28642789
sparser
"A Tr363 construct, three amino acids shorter but eliminating both putative palmitoylation sites, did not generate a receptor that could be detected by radioligand binding or PI hydrolysis, suggesting [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
14607266
sparser
"Palmitoylation of an α 1B AR-G q chimeric construct has been reported (Stevens et al., 2001) , but extensive further studies of the occurrence, regulation, and significance of α 1B AR palmitoylation a[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
14607266
trips
"A(1)AR palmitoylation is abolished by treatment with neutral hydroxylamine or by mutation of Cys-309 to Ala (C(309)-->A)."
10455026
sparser
"A(1)AR palmitoylation is abolished by treatment with neutral hydroxylamine or by mutation of Cys-309 to Ala (C(309)-->A)."
10455026
sparser
"Palmitoylation of a cysteine at position 341 (C-341; single letter amino acid abbreviations will be used throughout) in the -AR C-tail [8], and of two analogously placed cysteine residues in rhodopsin[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
8312128
sparser
"Palmitoylation of AR is likely to play a role in favoring AR plasma membrane anchorage, as observed with other sex steroid receptors ( Pedram et al., 2012 )."
34520815
sparser
"Here we describe S -palmitoylation of the β 3 AR."
30541923
sparser
"Sustained agonist stimulation favors the formation of unpalmitoylated β 2 AR species, most likely because of receptor phosphorylation, which prevents re-palmitoylation of β 2 AR ( Loisel et al., 1996 [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
20705094
sparser
"These results suggest that agonist-mediated regulation of beta 2-AR post-translational palmitoylation could represent an other regulatory process for G protein-coupled receptors."
1328244
sparser
"Palmitoylation of the classical androgen receptor (AR) has been reported to mediate rapid androgen effects [53] , although the inability of classical AR antagonists (flutamide, cyproterone acetate) to[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
37696380
sparser
"The possibility also exists that a small population of AR is actively transported to the plasma membrane in response to testosterone stimulation or that palmitoylation of some AR occurs that would fav[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
19095000
sparser
"When the level of testosterone is 10–250 nM, caveolin-1 mediates translocation of cytoplasmic palmitoylated AR to the membrane to initiate non-classical signaling ( Deng et al., 2017 )."
32470507
sparser
"However, site-directed mutagenesis of this residue has not been performed for any AR subtype, and no role for putative AR palmitoylation has been described."
10722120
sparser
"From DHHC-7 and -21 knockdown studies, the PATs are required for endogenous ER, PR, and AR palmitoylation, membrane trafficking, and rapid signal transduction in cancer cells."
22031296
sparser
"As reported, β 2 AR was palmitoylated at the 341st residue (cysteine; Fig. 1 A )."
27349735
sparser
"As in the case of ERs, caveolin-1 is important in prostate cells to promote the transport of palmitoylated AR to the caveolae at the membrane ( xref , xref ), and downregulation of caveolin-1 decreases AR membrane localization ( xref , xref )."
34791092
sparser
"Thus probably because DHHC-7 and -21, two palmitoylacyltransferase involved in the endogenous ER, PR, and AR palmitoylation [40] are not expressed in this tissue."
25263706
sparser
"A previous study found that ZDHHC21 is required for endogenous androgen receptor palmitoylation, membrane localization, and signal transduction in breast cancer cells [ xref ]."
38195819
sparser
"A previous study has shown that ZDHHC21 mediates endogenous androgen receptor palmitoylation and enhances membrane trafficking in breast cancer cells [ xref ]."
38195819
sparser
"Knockdown of DHHC-7 or -21 with siRNA diminished AR localization only at the PM ( xref ) and diminished AR palmitoylation ( xref )."
22031296