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USP18 binds Interferon and STAT2. 1 / 1

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"Two siblings with early onset autoinflammatory disease with neurological features and elevated IFN signature were additionally described with a homozygous missense mutation in STAT2 resulting in gain of activity due to the inability of mutant STAT2 to interact with the STAT2-dependent negative regulator of interferon activity, USP18 [ xref ]."

34258050

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IndraLab

Statements

USP18 binds Interferon and STAT2. 1 / 1

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