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"BRCA1-associated protein 1 (<span class="match term0">BAP1</span>) deubiquitinase antagonizes the ubiquitin-mediated activation of <span class="match term1">FoxK2</span> target genes. Okino Y(1), Machida Y(1), Frankland-Searby S(2), Machida YJ(3). Author information: (1)From the Departments of Oncology and. (2)Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota 55905. (3)From the Departments of Oncology and Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota 55905 machida.yuichi@mayo.edu. BRCA1-associated protein 1 (<span class="match term0">BAP1</span>), which is frequently mutated in cancer, functions as a deubiquitinase (DUB) for histone H2A.<span class="match term0">BAP1</span> represses <span class="match term1">FoxK2</span> target genes, and this effect requires <span class="match term0">BAP1</span> DUB activity but not interaction with HCF-1"