IndraLab

Statements

Pimozide inhibits USP1. 7 / 7
| 7
reach
"Further studies of the USP1/UAF1 inhibitors suggested that pimozide and GW7647 inhibit USP1/UAF1 by a non‐competitive mechanism and bind at a site other than the active site of USP1/UAF1 [113]."
24239534
reach
"Another study confirmed that pimozide could inhibit USP1 and in turn decrease the clonal growth of glioblastoma cells as well as increase their sensitivity to irradiation, though they are commonly resistant to chemotherapeutic and irradiation treatments (Lee et al., 2016)."
30851297
reach
"In this study, we showed that pimozide is a potent inhibitor of a human DUB, USP1 and UAF1, and provided insight into the molecular basis for the antineoplastic activity of pimozide."
22118673
reach
"Pimozide and GW7647 inhibit USP1 and UAF1 by a noncompetitive mechanism."
22118673
reach
"Another study confirmed that pimozide could inhibit USP1 and in turn decrease the clonal growth of glioblastoma cells as well as increase their sensitivity to irradiation, though they are commonly resistant to chemotherapeutic and irradiation treatments."
30851297
reach
"Pimozide and GW7647 inactivate USP1 and UAF1 in cells."
22118673
reach
"In order to demonstrate that pimozide and GW7647 inhibit the USP1 and UAF1 activity in cells, we developed an assay to determine the levels of Ub-PCNA or Ub-FANCD2 in cells treated with cisplatin, pimozide and GW7647 or a combination of cisplatin and pimozide and GW7647."
22118673