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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

ICP0 activates USP7. 2 / 2

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"Significant progress is being made on the development of therapeutics targeting USP7 and we direct the reader to recent studies and reviews of this area which we will not cover here.8 9 An early study of USP7 showed that it interacts with infected cell polypeptide 0 (ICP0) to activate Herpes simplex virus type 1 (HSV-1),10 hence the name HAUSP (in this review we refer to the protein as USP7)."

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"In the course of these studies we found and report here that ICP0 also targets USP7 for ubiquitination and proteasome dependent degradation."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...