IndraLab

Statements

ICP0 activates USP7. 2 / 2
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"Significant progress is being made on the development of therapeutics targeting USP7 and we direct the reader to recent studies and reviews of this area which we will not cover here.8 9 An early study of USP7 showed that it interacts with infected cell polypeptide 0 (ICP0) to activate Herpes simplex virus type 1 (HSV-1),10 hence the name HAUSP (in this review we refer to the protein as USP7)."
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"In the course of these studies we found and report here that ICP0 also targets USP7 for ubiquitination and proteasome dependent degradation."
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