IndraLab

Statements

USP14 binds IU1. 5 / 5
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"IU1 and its analogs can bound to USP14 and prevent the C-terminus of ubiquitin from approaching the catalytic center55."
34405018
sparser
"The co-crystal structures indicated some important key interactions between IU1 and USP14, including a unique and delicate π-π stacking interaction, which were validated by protein point mutations and inhibitor SAR analysis."
30254335
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"The mechanism of action of IU1 is different from bortezomib, which inhibits the activity of the entire proteasome, whereas IU1 binds specifically and inhibits USP14 (Lim et al., 2016)."
30319415
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"Herein, we report the high-resolution co-crystal structures of the catalytic domain of USP14 bound to IU1 and three IU1 derivatives."
30254335
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"Subsequently, we performed the design and optimization of new IU1-series inhibitors, including IU1-206, based on the structural information of the interaction between IU1 and USP14 (Figure 4A)."
35069211