IndraLab

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Mutated TP53 activates apoptotic process. 144 / 144
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"For example, mutant p53 3KR can not induce cell-cycle-arrest, senescence, or apoptosis, but it can still regulate metabolic target genes resulting in decreased ROS levels and reduced glycolytic flux."
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"The cell death was reported to be p53 independent because a p53 mutation failed to rescue the observed apoptosis XREF_BIBR."
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"MDM2 loss in p53 mutant/deleted TNBC cells in 2D/3D culture and TNBC patient explants, including relapsed tumors, causes apoptosis, while sparing normal cells."
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"In addition, the presence of p53 mutations in both drug resistant HOC313 and drug sensitive Ca9-22 cells indicates that p53 function is dispensable for determining the sensitivity to cisplatin induced[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
19852930
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"Targeting wild-type and mutant p53 with small molecule CP-31398 blocks the growth of rhabdomyosarcoma by inducing reactive oxygen species dependent apoptosis."
24027430
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"Accordingly, the rescued p53 mutants induced apoptosis by activating canonical WT p53 targets and delaying the cell cycle."
36765888
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"In skin cancer development, UVB induced mutation of p53 allows keratinocytes upon successive UVB exposures to evade apoptosis and cell cycle arrest."
25789975
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"This result suggested that the presence of CDKN2A and TP53 mutations allowed organoids to circumvent the apoptosis and senescence responses induced by the Wnt removal."
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"These include PRIMA-1 (p53 Reactivation and Induction of Massive Apoptosis), MIRA-1 (Mutant p53 reactivation and Induction of Rapid Apoptosis), and the methylated analog of PRIMA-1 (PRIMA-1MET or APR-246) [XREF_BIBR]."
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"While introduction of PRIMA-1 and APR-246-treated mutant p53 (thus covalently modified by MQ) into p53 null cells induces Puma, Bax, Noxa, and subsequent apoptosis [45], albumin treated in the same wa[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Moreover, GSEA showed that MAPK and apoptosis pathways induced by TP53 mutation were possibly associated with TACE failure and refractoriness."
32229792
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"These p53 mutants are unable to induce apoptosis, cell-cycle arrest, or senescence, yet retain the ability to prevent tumor formation in mice, suggesting that p53 induced ferroptosis could be responsible for tumor suppression."
29346757
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"We hypothesized that reactivation of mutant p53 in such tumors should trigger massive apoptosis and eliminate the tumor cells."
11875500
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"Repair of mutant p53 transcripts through trans-splicing was enough to induce apoptosis and cell cycle arrest in CRC cells, and suppress the growth of xenograft tumors."
25576916
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"This study was undertaken to dissect the molecular mechanism underlying sulindac induced apoptosis in human colon cancer cell line HT-29 (mutant p53), focusing on nuclear translocation of AIF, DFF and endonuclease G. On induction of apoptosis by sulindac, it was associated with decreased mitochondrial membrane potential, nuclear expression of active caspase-3, cleavage of poly (ADP-ribose) polymerase, translocation of mitochondrial proteins to the nucleus, and morphological evidence of nuclear condensation."
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"Many of the cell lines examined in this study express high levels of mutant p53, which may contribute to the strong apoptosis inducing effect of APR-246."
26086967
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"Saller, E., Tom, E., Brunori, M., Otter, M., Estreicher, A., Mack, D. H., Iggo, R. (1999) : Increased apoptosis induction by 121F mutant p53."
12067065
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"Integrity of the N-terminal transcription domain of p53 is required for mutant p53 interference with drug induced apoptosis."
11483519
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"Moreover, the overexpression of a number of transactivation-incompetent p53 mutants efficiently induces apoptosis."
26942128
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"The authors found that Lig4 -/-; p53 -/- mice developed B-cell lymphoma, but that introduction of a hypomorphic p53 mutant that fails to induce apoptosis but retains the ability to induce growth arrest and senescence (p53R172P) prevented the lymphomagenesis."
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"Further investigation is required to determine whether increase in the cytosolic mutant p53 following quercetin treatment in U373MG cells represses autophagy and promotes apoptosis through translocation to mitochondria."
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"Interestingly, many p53 mutants also lose the ability to induce apoptosis in a transcriptionally independent manner, despite retaining the ability to interact with BAK [105,107]."
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"Even though a few improvised p53-variants have been discovered mostly in terms of protein stability XREF_BIBR - XREF_BIBR, here we report a new p53 mutant that induces higher apoptosis by directly binding to a specific DNA sequence."
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"Consistent with this, Caelles and Karin XREF_BIBR found that apoptosis induced by stabilization of an ectopically expressed temperature sensitive mutant of p53 could proceed in the absence of RNA and protein synthesis."
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"Mutant p53 skin cancer cell lines were more resistant to IMQ induced apoptosis than wildtype p53 skin cancer cell lines."
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"The homozygous tp53 mutation as well as the tp53 knockdowns rescued retinal apoptosis in 50 hpf flo mutants (n = 25 flo and tp53 double mutants analyzed and> 200 tp53 morpholino injected larvae analyzed; XREF_FIG)."
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"Fe2O3 MFH can induce high Hsp70 expression at an early stage, enhance the expression of Bax, and decrease the expression of mutant p53, which promotes the apoptosis of tumor cells."
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"XREF_BIBR, XREF_BIBR UVB induced mutation of p53 allows keratinocytes upon successive UVB exposures to evade apoptosis XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR and cell cycle arrest."
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"Editor's Note: Peptide Aptamers Targeting Mutant p53 Induce Apoptosis in Tumor Cells."
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"Increased apoptosis induction by 121F mutant p53."
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"Reactivation of mutant p53 (mtp53) to a wild-type form using the small molecule " p53 reactivation and induction of massive apoptosis " (Prima-1) in nude mice bearing mtp53 human breast cell tumors restored the p53 directed apoptosis pathway and enhanced the exposure of PS in tumors."
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"A study on cell lines suggested that the mutant p53 activator, PRIMA-1, accelerated apoptosis and sensitized the tumor cells to chemotherapy [XREF_BIBR]."
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"A mutant P53 can activate apoptosis through a mechanism distinct from those induced by wild type P53."
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"In our prior work, we could not exclude apoptosis induced by a functionally active mutant p53, and therefore, in this present study, we used p53 null mice lacking any p53 protein expression."
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"Notably, over-expression of mutant p53 to levels sufficient to inhibit p21 transactivation nonetheless allowed significant transcription independent apoptosis to occur (14-16%)."
18547443
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"siRNA mediated downregulation of p53 in wild-type but not mutant p53 glioblastoma cells substantially impaired chloroquine induced apoptosis."
20308316
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"We have previously demonstrated that the introduction of Ad-p53 into glioma cells containing mutant p53 induces apoptosis, whereas glioma cells containing wild-type p53 are resistant."
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"Indeed, the overexpression of a mutant p53, lacking most of the DNA binding domain and completely deficient in transactivation function, can efficiently induce apoptosis in human cells."
25422906
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"PRIMA-1, a mutant p53 reactivator, induces apoptosis and enhances chemotherapeutic cytotoxicity in pancreatic cancer cell lines."
24838627
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"Mutant p53 impairs the DNA-damage response, and renders tumor cells more resistant to drug induced apoptosis."
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"Transcriptionally inactive p53 mutants can induce apoptosis in certain tumour cells."
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"In cancer cells sensitive to platinum based chemotherapy, wild-type p53 induces apoptosis and repair of damaged DNA, whereas chemotherapy resistant cancer cells include a mutant p53 that can not induce apoptosis of cancer cells and does not inhibit cancer cell growth [XREF_BIBR]."
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"Transformed cells evade p53 dependent apoptosis initiated by Rb inactivation by TP53 mutation."
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"Screening of the diversity set from the National Cancer Institute led to the discovery of some chemical chaperones with mutant p53 reactivating capacity : compound 854 known as PRIMA-1 (p53 reactivation and induction of massive apoptosis) and compound 954 known as MIRA-3 (mutant p53 dependent induction of rapid apoptosis)."
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"We have shown that the Fas-transduction pathway is activated only by wild-type p53 and not by mutant p53 [35] and that apoptosis induced by p53p-Ant in mutant p53 tumor cells is mediated via the Fas p[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12413961
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"Indeed, downregulation of mutant p53 in T47D (p53 L194F), MDA-MB-231 (p53 R280K), and MDA-MB-468 (p53 R273H) breast cancer cell lines induces PARP dependent apoptosis."
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"However, mutant p53 can also induce apoptosis through a transcription independent pathway, in which wild-type p53 and p53 mutants are transiently located to the mitochondria with changes in the mitochondrial membrane potential [XREF_BIBR]."
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"Along this line, mutant p53 avoids inducing apoptosis and enhances cell survival upon etoposide treatment through upregulation of NF-κB2 [169], a transcription factor that mediates expression of cell cycle and anti-apoptotic genes."
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"Furthermore, in multiple myeloma, MIRA (mutant p53 reactivation and induction of rapid apoptosis) 1 can restore the p53 function and p53-induced cancer cell apoptosis with a higher potency than PRIMA-1 [153]."
| PMC
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"Although the magnitude of the enhancement of apoptosis caused by mutant p53 downregulation varied between cell lines, inhibition of mutant p53 expression caused a consistent increase in drug induced a[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12726864
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"It has been reported previously that the overexpression of human p53 gene induced apoptosis in the transgenic mouse lens and that the apoptosis was rescued by a p53 mutant transgene, which can interfere with p53 normal function."
20484573
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"A validation sample of 15 CLL carrying TP53 mutations, of which 13 carried both del17p and a TP53 mutation confirmed substantially less sensitivity to ibrutinib induced apoptosis."
27535981
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"P53 mutation rescues apoptosis in the flo retina and optic tectum, but not in the intestine, where the checkpoint kinase Chk2 is activated."
18974873
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"SiRNA knockdown of mutant p53 reduces the apoptosis inducing effects of APR-246 in ES cells."
24129240
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"Data have demonstrated that p53 mutants lacking a transactivation domain can induce apoptosis, and activation of p53 in the absence of a nucleus also triggers apoptosis, demonstrating that cytoplasmic p53 can induce apoptosis through a transactivation independent mechanism."
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"In addition, the mutation of TP53, a tumor suppressor gene, can induce unlimited proliferation and apoptosis resistance of tumor cells."
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"Kokontis et al. reported that wild type p53 induces cell cycle arrest in a p21 dependent manner, without apoptosis, whereas a p53 mutant (defective in trans-activation) induces apoptosis without cell cycle arrest [55]."
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"In tumor cells, the emergence of MK2 as an alternative cell-cycle checkpoint, responsible for resistance to apoptosis caused by p53 mutation, has put forward MK2 as an effective target for combination based cancer therapies [XREF_BIBR]."
30850014
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"However, mutant p53 without p53 peptide does not induce a Fas and APO -1 activation or apoptosis."
10574967
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"Indeed, based on crystallographic structural and computational analyses, PRIMA-1 (p53 reactivation and induction of massive apoptosis-1) and MIRA-3 (mutant p53 reactivation and induction of rapid apoptosis in vivo) were developed to convert mutant p53 and restore p53 function leading to effective activation of downstream apoptosis inducing targets, such as caspase-2, puma, and Bax [XREF_BIBR, XREF_BIBR]."
25806108
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"Therefore, we explored the role of mutant p53 status in NL induced apoptosis."
29107110
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"Moreover, PTEN over-expression failed to sensitize the chemoresistant p53 mutant ovarian cancer cell line A2780-cp to cisplatin induced apoptosis, unless wild-type p53 was reconstituted by adenoviral p53 infection."
16545436
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"Knockdown of mutant p53 by RNA interference causes massive apoptosis in mutant p53 breast cancer cell lines but not in wild-type p53 breast cancer cell lines, indicating that mutant p53 may confer oncogenic potential as well as loss of tumor suppressor activity [XREF_BIBR]."
20707913
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"13 TP53 mutations enable tumor cells to resist apoptosis and expand clonally at the expense of neighboring normal keratinocytes."
29332704
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"Mutant p53 dependent induction of rapid apoptosis (MIRA-1)."
24756955
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"Repair of mutant p53 transcripts by trans-splicing induced cell-cycle arrest and apoptosis in p53 defective colorectal cancer cells in vitro and in vivo."
25576916
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"Overexpression of p53, but not mutant p53, in wild-type and mutant neuroblastoma cells was sufficient to induce apoptosis, which, in turn, was reduced by TUDCA."
16923170
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"Eventually, checkpoint genes such as TP53 are targeted, and the mutations of TP53 allow cells to escape the fate of apoptosis and senescence, and facilitate tumor progression."
33299637
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"A mutant p53 that discriminates between p53 responsive genes can not induce apoptosis."
8756655
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"Homozygous p53 mutation completely rescued CNC migration and apoptosis, and Pax3 LacZ and LacZ p53 -/- embryos were indistinguishable from Pax3 LacZ/+ embryos at the 24-28 somite stage (XREF_FIG, compared to XREF_FIG), as well as at earlier somite stages (not shown)."
18672055
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"Our result suggests that mutant p53 in U373MG cells can induce apoptosis through a transcription independent pathway, as the level of cytochrome c increased in the cytosolic fraction, whereas the level of cytochrome c decreased in the mitochondrial fraction with a decrease in mitochondrial membrane potential (XREF_FIG)."
24379902
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"However, there is substantial evidence showing that mutant p53 is still able to induce apoptosis through different mechanisms."
27409664
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"Similarly, G. Blandino and M. Oren suggested that some of the p53 mutants that are frequently detected in primary human tumors efficiently interfere with drug induced apoptosis."
9875245
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"The apoptosis of cervical squamous carcinoma cells in the group treated with the mutant p53 + gC1qR vector was lower than that in the empty pCB6 vector + gC1qR vector group (p < 0.05)."
23268996
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"Hence, RIG-I and MDA5-driven apoptosis is not mediated by the tumor suppressor p53 mutational status in cancer cells, which strongly contributes to resistance to chemo- and radiotherapy."
29686682
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"Our results demonstrate the impact and in vivo relevance of non transcriptional mechanisms for wild-type and mutant p53 mediated apoptosis."
16247471
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"Furthermore, current studies suggest that reactivation of mutant p53 proteins in tumours using small p53 activating molecules may initiate p53 dependent apoptosis and thus eliminate the tumour."
9951684
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"8 Mutant p53 is frequently observed in cancer and is often associated with a loss of function to induce cell cycle arrest and apoptosis."
26148235
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"Our results suggest that increased DNA instability, enhanced proliferative activity, p53 mutation, and induction of DFF45 and VEGF may allow cancer cell proliferation, enhance their survival by escaping apoptosis, and provide abundant nutrients during early-stage carcinogenesis of oral leukoplakia."
11846001
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"Indeed, the mutant p53 that produces amino acid residues 1-214 and induces apoptosis in HeLa cells fails to induce apoptosis in another cell type, a human lung carcinoma, cell line H1299 (Haupt et al.[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
9039259
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"Thus, reactivation of mutant p53 proteins may trigger massive apoptosis in tumor cells."
20139776
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"Importantly, accumulation of mutant p53 may induce apoptosis due to activation of DNA damage pathway which was validated by γH2.AX expression in PHY34 treated cells (Supplemental Fig. 4E)."
35013112
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"These observations together with our biochemical and cellular data, provide insights into the transcription-independent activity of p53-mediated mitochondrial apoptosis and the mechanism of its inactivation by p53 mutations."
33863900
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"These results suggest that several distinct features, such as the primary sequence of the antibody, affinity for the target epitope, or the specific cellular environment, may determine the efficacy of[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
10725451
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"Increased expression of mutant p53 induces failure of apoptosis."
20427942
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"This suggests that the integrity of the N-terminus is essential for both the activity of wild-type p53 in apoptosis and for mutant p53 mediated block of drug induced apoptosis."
11483519
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"Many human cancers contain a p53 mutation, which can mediate resistance to chemotherapy induced apoptosis."
26021465
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"This findings support the results obtained from SW480 experiments, thus overall suggesting that mutant p53 protects cells from chemotherapy-induced apoptosis in a GOF manner."
29343849
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"The overexpression of a mutant p53, lacking most of the DNA binding domain (DBD) and completely deficient in transactivation function, still triggers apoptosis."
26942128
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"Several studies have shown that the p53 mutants with defects in transcription activity are still able to induce apoptosis."
27818144
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"One explanation for this finding was a possible mechanism involving protein modification via covalent binding to the ITC functional group, making the mutant p53 cells significantly more sensitive to P[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
24625788
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"To distinguish the mechanism for the mutant P53 induced apoptosis from that of wtP53, we first confirmed that the P53 gly (281) had lost P53 specific transactivation activity in PC3 cells by demonstra[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12062426
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"Actinomycin D, a potent inhibitor of transcription, as well as a DNA damaging agent, abrogated the restraint apoptosis mediated by mutant p53."
9681825
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"Further mechanism assay showed silencing RRM2 lead to inactivation of PI3K/AKT/mTOR pathway and inhibition of mutant p53, which induce S phase arrest and/or apoptosis."
35300916
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"Mutant p53 reactivation will restore p53 dependent apoptosis, resulting in efficient removal of tumor cells."
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"Further, the requirement for transactivation by p53 for triggering at least some of its cellular responses is emphasized by the inability of a transactivation deficient p53 mutant to activate apoptosi[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
18471976
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"Inversely, adenoviral vector transfection of the wild-type p53 tumor suppressor gene by Bouvet et al. in mutant p53 MIA-PaCa-2 and PANC-1 induced apoptosis and inhibited tumor cell growth [XREF_BIBR]."
26606261
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"MIRA-1 (mutant p53 reactivation and induction of rapid apoptosis) is a maleimide derived molecule and has no structural similarity with PRIMA-1, but it is equally able to restore p53 function leading to cell death via apoptosis with even higher potency than PRIMA-1."
25374842
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"Covalent modification of mutant p53 per se is sufficient to induce apoptosis in tumor cells."
19411067
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"This has led to the identification of a peptide and some small molecules, including CP-31398, ellipticine, WR1065, MIRA-1 (mutant p53 dependent induction of rapid apoptosis) and their derivatives that were found to rescue WT activity of several misfolded mutants."
18182973
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"Mutant p53 (p53 3KR) that can not cause arrest, senescence and apoptosis still suppressed tumors in mice [XREF_BIBR, XREF_BIBR]."
22869016
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"Targeting wild-type and mutant p53 with small molecule CP-31398 blocks the growth of rhabdomyosarcoma by inducing ROS dependent apoptosis."
20682800
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"This is presumably mediated by the inability of the mutant p53 to recognize DNA damage and initiate events to either repair the damage or promote apoptosis."
22353361
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"Inhibition of TAp63 or TAp73 has no effect on apoptosis induced by mutant p53 knockdown (XREF_FIG)."
19773755
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"Furthermore, we have found that the shRNA mediated mortalin silencing could induce mutant p53 mediated tumor specific apoptosis in HCC."
21165951
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"Fe 2 O 3 MFH can induce high Hsp70 expression at an early stage, enhance the expression of Bax, and decrease the expression of mutant p53, which promotes the apoptosis of tumor cells."
25296356
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"Overexpression of Bcl-2 in the mammary gland using a whey acidic protein (WAP) promoter driven Bcl-2 transgene inhibits apoptosis in the mammary gland during pregnancy, lactation, and involution, and also counteracts apoptosis induced by overexpression of a mutant p53 transgene (WAP-p53 172 R-L)."
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"Combined mutations of p53 K117, K161, and K162 to arginine (3KR) in mouse result in loss of induction of apoptosis, senescence, and cell cycle arrest by the mutant p53 3KR protein [XREF_BIBR]."
29484110
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"Along these lines, while the p53 mutant is unable to promote apoptosis in response to acute DNA damage, it retains substantial apoptotic activity in response to non-genotoxic stresses such as hypoxia [52]."
34103683
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"Pharmacological reactivation of mutant p53 would restore p53 dependent senescence and apoptosis, and presumably also p53 mediated regulation of metabolism and other processes, and thus eliminate tumors in vivo."
26870698
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"First, p53 mutation rescued apoptosis in the flo retinal epithelium even though the NPC defect persisted in all of the double mutant cells we analyzed."
18974873
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"Several years ago, Oren and colleagues XREF_BIBR noted that over-expression of a mutant p53, lacking most of the DNA binding domain and completely deficient in transactivation function, could nonetheless trigger apoptosis."
19407794
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"When treated with CDDP, transfection of TP53 wild-type NUGC4 and TP53 mutant MKN7 with siRNA-TRIM37 increased early apoptosis, at 72 h post-transfection, compared with transfection with control siRNA."
33391428
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"Similarly to MIRA-3 (mutant p53 reactivation and induction of rapid apoptosis), and STIMA-1 (SH group targeting and induction of massive apoptosis), which also rescue mutant p53 function via thiol modification within the DNA binding domain, PRIMA-1 increased p53 activity by restoring sequence specific DNA binding, and triggered the mitochondria dependent intrinsic apoptosis program via activation of caspase-2 [XREF_BIBR]."
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"These results indicated that the tumor growth inhibition of SNL-P administration might correlate with the reduction of TNF-alpha level of blood serum, which resulted in a massive necrosis in tumor tissues and the up-regulation of Bax and down-regulation of Bcl-2 and mutant p53 gene expression, which triggered apoptosis in tumor cells."
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"Transfection of p53 mutant human glioblastoma cells corrected the mutation and induced apoptosis in 7.5% of cells."
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"We have previously shown that apoptosis is increased in YAMC cells treated with E 2 The introduction of the dominant negative mutant p53 175H not only prevents induction of apoptosis by E 2, but signi[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
22100717
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"In this scenario, we previously demonstrated that the combination of ibrutinib with MDM2-inhibitors synergized in promoting apoptosis in B-CLL cell lines carrying wild-type p53 as well as 17p13 deletion and/or TP53 mutations [16], and that ibrutinib combined with gamma-secretase inhibitors exhibited enhanced cytotoxicity that was coupled with the down-regulation of the c-MYC oncogene [8]."
34287267
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"Therefore, mutation of the p53 gene, which correlates closely with p53 protein overexpression, would be predicted to activate cell proliferation and limit apoptosis."
7551342
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"Many of these mutant p53 proteins have oncogenic characteristics, and therefore modulate the ability of cancer cells to proliferate, escape apoptosis, invade and metastasize."
34952583
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"We suggest that the resistance of MNNG and HOS cells to drug induced apoptosis is caused by the up-regulation of p21 (WAF1) by the mutant p53 (transcriptional activity was shown by p53 siRNA treatment) which induces cell cycle arrest and allows to repair DNA damage."
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"In contrast, others have shown that the same p53 mutant was unable to induce apoptosis [18-20]."
12062426
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"Our data manifested that both PFH-G9 and TAM significantly decreased p53 levels in T47D that expresses mutant p53 in T47D of breast cancer cell line that led to massive apoptosis."
29323210
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"Several other p53 mutants have also been shown to induce apoptosis or cell-cycle arrest independent tumor suppressor activities."
24387338
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"If this is the case, depletion of mutant p53 should restore the TNFalpha dependent accumulation of Daxx and induces apoptosis in cells."
19789335
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"In contrast, this phenomenon was not observed in p53-knockdown cells (shTP53), suggesting p53 mutations increase cell apoptosis in lung cancer cells treated with simvastatin (Fig. 2F)."
31892709
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"Introduction of mutant p53 into HK-1 cells resulted in growth enhancement in vivo and increased resistance to SarCNU induced apoptosis in vitro."
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"Also, knockin mice carrying a mutant p53 (p53 K117R; K161R; K162R) that can not induce cell cycle arrest, apoptosis, and senescence fail to develop tumors at an early age, unlike p53-null mice, likely because p53 K117R; K161R; K162R retains the abilities to regulate energy metabolism and reduce reactive oxygen species [XREF_BIBR]."
29597309
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"Our results demonstrate a potent dominant negative inhibitory effect of a single mutant p53 allele (p53 +/R172H) on UVB induced lincRNA-p21 transcript levels and UVB induced apoptosis."
25789975
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"HT29 cells have a point mutation in the transactivation domain of p53 (R273H), but studies have shown that this mutant p53 induces apoptosis or cell cycle arrest upon various challenges."
25918225
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"Furthermore, tumour protein p53 (p53) signalling is a key pathway in apoptosis triggered by cisplatin [XREF_BIBR] and p53 mutations are often associated with cisplatin resistance [XREF_BIBR]."
29518977
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"Mutant p53 mediated induction of cell cycle arrest and apoptosis at G1 phase by 9-hydroxyellipticine."
10652599
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"Enhancing endogenous ceramide by disrupting ceramide glycosylation sensitizes mutant p53 cells to drug induced apoptosis, even though it does not significantly alter p53 protein levels, as reported previously and detected by Western blotting in the present study (XREF_FIG, XREF_FIG, XREF_FIG, XREF_SUPPLEMENTARY)."
21278235
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"Deletion of this proline rich region of the p53 protein permits normal p53 mediated transcriptional activation but significantly reduces the ability of this p53 mutant protein to mediate apoptosis or [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
9039259
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"It is reported that the mutation of p53 can cause alteration of growth arrest and deficient apoptosis."
30127956
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"The DBTRG-05MG (TP53 wild-type) and U251 (TP53 mutant) cell lines were shown to be sensitive and resistant to miR-29s induced apoptosis, respectively, which was consistent with the findings discussed above."
30348972
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"XREF_BIBR On the other hand, mutant p53 protein has been shown to be activated by small molecule drugs such as PRIMA-1 and is able to induce apoptosis in bladder cancer cells including T24 similar to the wild-type protein."
27784990
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"Further studies showed directly that some p53 mutants which retained the ability to activate waf-1 expression and were able to block cells in the G1 stage of the cell cycle, were nevertheless unable t[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
8806187
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"Suberoylanilide hydroxamic acid enhances the radiosensitivity of lung cancer cells through acetylated wild-type and mutant p53 dependent modulation of mitochondrial apoptosis."
33557658
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"Apoptotic cell analysis showed that transfection of TP53 wild-type NUGC4 and TP53 mutant MKN7 with siRNA-TRIM37 increased early apoptosis (annexin V-positive and PI-negative) and late apoptosis (annexin V/PI-double positive), respectively, at 72 h post-transfection compared with transfection with control siRNA."
33391428
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"MDM2 knockdown in p53 mutant NSCLC H2009 cells induced significant cell cycle arrest, apoptosis and growth inhibition through upregulation of p21 and activation of caspase-3."
23352573
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"Targeting wild-type and mutant p53 with small molecule CP-31398 blocks the growth of rhabdomyosarcoma by inducing reactive oxygen species dependent apoptosis."
20682800
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"The results obtained show that knockdown of mutant p53 (shp53) significantly increased apoptosis following chemotherapy treatment compared with that seen in the shCon cells, suggesting that mutant p53 protects cells from chemotherapy-induced apoptosis."
29343849
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"Most relevantly, under conditions such that H115N induced equivalent levels of p21 as WT p53, there was still a selective impairment in apoptosis induced by the mutant p53."
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