IndraLab

Statements

SCN5A activates (-)-epicatechin-3-O-gallate. 6 / 6
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"Six gene variants were found including a novel missense mutation of base C to T, named Arg965 Cys (R965C), which located in 965 codon of the 17 exon in SCN5A, and five SCN5A polymorphisms including A29A (c. 87A> G), R1193Q (c. 3578G> A), D1819D (c. 5457T> C), exon11 -24 G> A, exon23 +4 A> G. SCN5A mutation is related to fever induced Brugada ECG pattern."
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"Heavy metals like zinc and copper can serve as endogenous regulators of sodium, potassium, and calcium channels, including NaV1.5 sodium channel, which might possibly produce a Brugada ECG pattern ."
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"The SCN5A–SCN10A locus (lead SNP rs10428132) was significantly associated with ajmaline-induced Type I BrS ECG (P = 8.6 × 10 )."
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"The activity of REs is largely limited to target genes that fall within the same TAD , including SCN5A, SCN10A, EXOG, SCN11A, and WDR48.GWAS have identified genetic variants in the SCN5A-SCN10A locus that modulate ECG parameters and contribute to conduction diseases."
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"Over-expression of the SCN5A gene leads to a shorter P wave duration and PR interval in transgenic mice ECG [16], which suggests that Na 1.5 interference or blockade caused prolonged P wave duration, as observed in this report.Isorubijervine and rubijervine treatment shortened the QT interval in rats (Figure 2), which is the same as other sodium channel blockers."
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"Conclusion: Short-term treatment with antidepressant drugs increase DNA methylation in KCNE1 and SCN5A promoters, which may induce ECG alterations in psychiatric patients."
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