IndraLab

Statements

CYLD inhibits IL4. 2 / 2
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"IL-4 produced by CYLD-deficient Treg cells also appeared to impact conventional Th2 cells expressing type 2 cytokines such as IL-4 and IL-5, providing another mechanism to further boost type 2 immunity against helminth infection."
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"Strikingly, CYLD-deficient Treg cells strongly produced IL-4 protein compared to WT Treg cells that had minimal expression of IL-4 (Fig 3, A), and other cytokines were also elevated in CYLD-deficient Treg cells albeit to a lesser extent."
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