IndraLab

Statements


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"Thus, even though DNA binding by either UAF1 or RAD51AP1 is sufficient for targeting the USP1-UAF1-RAD51AP1 DUB complex to DNA for FANCD2 deubiquitination, the DNA binding attribute of both UAF1 and RAD51AP1 is required for optimal DNA damage repair."

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"UAF1-USP1 readily associates with RAD51AP1 to form a trimeric complex ( xref )."

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"In line with our findings and with results from others , Wagner et al. showed that RAD51AP1 interacts with UAF1-USP1, but also with USP7 and USP11, DUBs with important roles in the cellular response[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

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"UAF1-USP1 readily associates with RAD51AP1 to form a trimeric complex ( Figure S3 F)."