IndraLab

Statements

BECN1 binds USP14. 13 / 13
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"Interestingly, 6-Gingerol treatment significantly suppressed USP14 expression, indicating that 6-Gingerol promoted autophagy effected by inhibition of USP14-Beclin 1."
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"To characterize interaction between USP14 and Beclin 1, we generated truncated mutants of Beclin 1."
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"Immunoprecipitation was performed and we found that BECN1 could interact with USP14 ( xref xref ))."
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"To characterize interaction between USP14 and Beclin 1, we generated truncated mutants of Beclin 1 (Figure xref A)."
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"Binding of USP14 with Beclin 1 was significantly abolished upon deletion of its CC domain, suggesting that the CC domain of Beclin 1 was important for the interaction."
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"Thus, the USP14–UVRAG axis has an opposite effect to the USP14–BECN1 axis."
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"Notably, 6-Gin treatment significantly supressed USP14 expression, indicating that 6-Gin promoted autophagy effects by inhibition of USP14-Beclin 1, which was consistent with previous study ( xref )."
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"However, the study does not provide any evidence for the catalytic role of USP14 and instead suggests that the interaction of Beclin1 with USP14 inhibit TRAF6-mediated ubiquitination of Beclin1 [ xref ]."
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"However, the study does not provide any evidence for the catalytic role of USP14 and instead suggests that the interaction of Beclin1 with USP14 inhibit TRAF6-mediated ubiquitination of Beclin1 [73]."
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"Binding of USP14 with Beclin 1 was significantly abolished upon deletion of its CC domain (Figure xref B, lane 3), suggesting that the CC domain of Beclin 1 was important for the interaction (Figure xref B in Supplementary Material)."
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"With increasing amount of USP14, in contrast, the interaction between Beclin 1 and USP14 was gradually increased."
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"With increasing amount of USP14, in contrast, the interaction between Beclin 1 and USP14 was gradually increased (Figure xref A, lanes 3–5 in Flag-USP14)."
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"Co-transfection assay with Myc-Beclin 1 and Flag-USP14 in HEK293T cells revealed that Flag-USP14 interacted with Myc-Beclin 1."
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