IndraLab

Statements

COPS5 activates DNA repair. 5 / 5
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"Recently, we found that Jab1 and Csn5 positively regulates the DNA repair gene Rad51 and contributes to radiation resistance in NPC; Therefore, we hypothesized that Jab1 and Csn5 participates in the process of recurrence after radical radiotherapy in NPC patients."
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"It was reported that RECK inhibited the Her2 signaling and attenuated the expression of Jab1 and Rad51 to impede DNA repair in SKBR3 breast cancer cells."
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"Inhibition of CSN5 inhibited its oncogenic function by targeting AR signaling, DNA repair, multiple oncogenic pathways, and spliceosome regulation."
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"Recently, we found that the aberrant activation of Jab1 overexpression is correlated with a lower survival rate in NPC patients 14 and that Jab1 positively regulates the DNA repair gene Rad51 and contributes to NPC cells ' response to radiotherapy and cisplatin 15."
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"These results indicate that Jab1/CSN5 deficiency enhances DNA damage and decreases DNA repair after exposure to DNA damage stimuli.An interesting connection between Jab1/CSN5 and the hypoxia-inducible[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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