IndraLab

Statements

Modified USP14 increases the amount of Ubiquitin. 2 / 2
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"Biochemical analysis showed that the ubiquitin hydrolyase activity of this form of Usp14 is dependent on the presence of proteasomes, and neuronal expression of full-length Usp14 was able to restore the levels of monomeric ubiquitin in the brains of axJ mice."
17079671
reach
"Analysis of spinal cord and sciatic nerve extracts from the ax J -Tg mice demonstrated that transgenic expression of Usp14 restored monomeric ubiquitin levels back to wt levels (XREF_FIG), indicating that Usp14 is required for the maintenance of monomeric ubiquitin in the spinal cord and motor neuron axons."
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