IndraLab

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CYLD binds HES1. 2 / 2
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"Using a conventional ChIP assay in human Hes1 + T-ALL cells and a Hes1 antibody followed by PCR with specific primers flanking the identified putative N-box sites, we were able to show that endogenous Hes1 binds to the predicted PRO2 site in the CYLD 5’UTR ( xref ) and this association was lost following Hes1 knock-down ( xref ) as measured by qPCR."
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"Endogenous Hes1 protein could bind the CYLD promoter in T-ALL cells, and the CYLD expression levels were found to be significantly decreased in most human primary T-ALL samples analyzed."
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