IndraLab

Statements

USP11 binds USP7. 32 / 32
7 | 6 19
biogrid
No evidence text available
26496610
sparser
"In both cases, USP7 binding by USP11 was greatly decreased by the S687A mutation but not the S562A and S671A mutations."
30367141
sparser
"A previous study showed that USP11 and USP7 interact, and this interaction is lost in USP7 D164AW165A and USP11 S687A mutants ( xref )."
33567341
sparser
"USP11 forms a complex with USP7 to deubiquitinate the oncogenic lymphocyte cell-specific protein-tyrosine kinase (LCK) and enhance its activity."
36490346
reach
"The above experiments showed that USP11 binds USP7 through the TRAF binding pocket."
30367141
sparser
"However, it is not clear whether they bind simultaneously within the same complex and the situation is complicated by the fact that USP7 and USP11 also interact with one another ( xref ; xref )."
20601937
sparser
"MYCN de-ubiquitylation and hence stabilization by USP11–USP7 enables it to recruit the tumor suppressor BRCA1to promoters ( xref )."
32071436
sparser
"Our finding that USP7 and USP11 physically interact raise the possibility that they function as a complex to regulate the levels and activities of their shared binding partners."
30367141
sparser
"Sowa and colleagues indeed confirmed the interaction between USP11 and USP7."
29293652
sparser
"Notably, USP7 interacts with USP11 through the P/A/ExxS motif in USP11, regulates USP11 stability [ xref ], and USP7 and USP11 act cooperatively in modulating Polycomb regulation of the INK4a tumor suppressor [ xref ]."
33991872
reach
"Since the AGPS sequence matches P/A/ExxS motifs known to bind USP7 directly, our results suggest that USP7 binds directly to USP11."
30367141
sparser
"In gastric carcinoma cells, affinity purification, in conjunction with mass spectrometry, was performed for pinpointing USP7 binding targets. xref , xref The findings of this study are in concordance with those of previous reports as per which TRIP12 E3 ubiquitin ligase, PPM1G phosphatase, and USP11 were associated with USP7."
35005106
sparser
"This residue promotes MYCN turnover, as its dephosphorylation causes MYCN to bind the de-ubiquitylase USP11–USP7."
32071436
reach
"In both cases, USP7 binding by USP11 was greatly decreased by the S687A mutation but not the S562A and S671A mutations."
30367141
biogrid
No evidence text available
19615732
sparser
"Using a series of deletion mutants of MEL18, we further showed that both USP7 and USP11 associate with the amino terminal region of the protein, which includes the RING domain ( xref )."
20601937
biogrid
No evidence text available
20601937
reach
"It is also possible that USP7 binding to USP11 could inhibit its catalytic activity, since the USP7 binding site falls within an insert in the USP11 catalytic domain."
30367141
sparser
"This confirmed reported associations of USP7 with USP11, PPM1G phosphatase and TRIP12 E3 ubiquitin ligase as well as identifying novel interactions with two DEAD/DEAH-box RNA helicases, DDX24 and DHX40."
30367141
sparser
"Notably, SPRTN auto-cleavage increased in USP11-USP7 double-knockdown cells ( xref B , lane 7) compared with USP11 or USP7 single knockdown, suggesting that USP11 and USP7 may function together in regulating SPRTN auto-proteolysis."
33567341
biogrid
No evidence text available
22411829
sparser
"Like USP7, USP11 appears to have multiple cancer-associated roles, that could either promote or suppress oncogenesis xref – xref and therefore a better understanding of the USP7-USP11 interaction is warranted."
30367141
reach
"USP11 forms a complex with USP7 to deubiquitinate the oncogenic lymphocyte cell-specific protein-tyrosine kinase (LCK) and enhance its activity."
36490346
sparser
"It is also possible that USP7 binding to USP11 could inhibit its catalytic activity, since the USP7 binding site falls within an insert in the USP11 catalytic domain."
30367141
sparser
"The above experiments showed that USP11 binds USP7 through the TRAF binding pocket."
30367141
sparser
"Since the AGPS sequence matches P/A/ExxS motifs known to bind USP7 directly, our results suggest that USP7 binds directly to USP11."
30367141
biogrid
No evidence text available
20601937
biogrid
No evidence text available
19615732
biogrid
No evidence text available
19615732
sparser
"USP11 and USP7 interact and have common targets such as XPC and components of the PRC1 complex."
33567341
reach
"Sowa and colleagues indeed confirmed the interaction between USP11 and USP7."
29293652
sparser
"Here, we show that USP7 and USP11 are associated with chromatin and bind to several PRC1 components in high-molecular-weight complexes."
20601937