IndraLab
Statements
reach
"The protein levels of Fbx4 could not be rescued by overexpression of wild-type mouse CSN5, suggesting that loss of Fbx4 arose from a promiscuous effect of the CSN5 directed siRNA and was not due to Csn5 knockdown (data not shown), Therefore, the reduction in Skp2 and cyclin F levels in Csn5 depleted cells is caused by the loss of CSN isopeptidase activity."