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COPS5 inhibits calcium(2+). 8 / 8
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"Here, we report that transcription coactivator CSN5 interacts with the intracellular II-III linker of the alpha 1C subunit of cardiac L-type Ca 2+ channel in vivo and inhibits channel activity.Overexp[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In rat, CSN5 inhibits cardiac L-type Ca 2+ channel activity through protein protein interactions."
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"Inhibition of CSN5 expression by siRNA enhanced the L-type Ca 2+ currents."
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"Thus, the possible mechanisms by which CSN5 inhibits L-type Ca 2+ channels might be through an inhibition of the expression of the alpha 1C subunit at the cell surface membrane and/or a reduction of a[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"These data indicate that inhibition of endogenous CSN5 in COS7 cells enhances the activity of recombinant L-type Ca 2+ channels.Inhibition of CSN5 expression had no effect on the kinetics of L-type Ca[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Thus, the possible mechanisms by which CSN5 inhibits L-type Ca channels might be through an inhibition of the expression of the α subunit at the cell surface membrane and/or a reduction of availabilit[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Because endogenous CSN5 expressed in COS7 cells may interact with and regulate the expressed Ca 2+ channels, we next examined effects of the inhibition of endogenous CSN5 on the Ca 2+ currents.Inhibit[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"The result suggests that endogenous CSN5 expressed in COS7 cells interacts with recombinant cardiac L-type Ca 2+ channel and that the endogenous protein level of CSN5 in these cells is sufficient to i[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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