IndraLab

Statements

E6 inhibits CYLD. 6 / 6
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"The E6 oncoprotein is also able to promote the uniquitination and proteasomal degradation of the negative NFκB regulator cytlindromatosis (CYLD) lysine 63 deubiquitinase, in hypoxic conditions, common[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"It is also plausible that post-translational hydroxylation may take place on a protein involved in formation of a protein complex that includes E6 and CYLD, whereby hydroxylation impairs complex formation and, by extension, the ability of E6 to target CYLD for ubiquitination."
18977328
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"In cancer cell lines, infected with high-risk human papillomavirus (HPV) serotypes, HPV-encoded E6 protein ubiquitinates and degrades CYLD leading to prolonged NF-κB activation [ 28 ]."
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"Importantly, degradation of CYLD by E6 was prevented by treatment of cells with the proteasome inhibitor, MG132 (XREF_FIG)."
18977328
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"As HPV16 E6 inactivates CYLD XREF_BIBR and because defective CYLD causes enhanced nuclear import of BCL-3, we reasoned that HPV16 E6 may induce KIAA1199 expression through BCL-3 in transformed keratinocytes."
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"In preclinical models, under hypoxic conditions, the HPV encoded E6 protein promotes inactivation and degradation of the CYLD tumor suppressor, resulting in prolonged activation of NF-kappaB pathway [XREF_BIBR]."
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