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Catalytically active CYLD increases the amount of reactive oxygen species. 1 / 1
1 |

"we found that ROS production as measured by flow cytometry or by confocal microscopy was reduced in CYLD-/- MEFs (Figure 9A-B). Therefore, despite relatively normal assembly of the necrosome, CYLD-/- cells were defective for downstream signaling such as ROS production."