IndraLab

Statements

UCHL5 activates Neoplasm Metastasis. 9 / 9
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"Ubiquitin C-terminal hydrolase L5 ( UCHL5 ) has been found to aggravate tumor growth and metastasis in several different types of tumor models such as esophageal squamous cell carcinoma , hepatocellular carcinoma , and epithelial ovarian cancer ."
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"The ability of UCHL5 to promote metastasis can be increased by using β-catenin inhibitors or decreased by using β-catenin (Fig. 5B and D)."
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"UCHL5 combined with DRAIC can increase the proliferation and metastasis of GC cells via ubiquitination [28]."
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"Notably, we discovered that overexpression of UCHL5 significantly enhanced the lung metastases burden of BxPC-3 cells in contrast to that in the control group, as indicated by the luciferase signals a[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"UCHL5 promotes the proliferation and metastasis of HCC cells in vivo."
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"UCHL5 promotes the growth and metastasis of HCC cells in vitro."
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"The results show that the knockdown of UCHL5 significantly inhibited HCC cell metastasis."
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"These findings demonstrate that UCHL5 promotes the in vitro proliferation and metastasis of HCC cells."
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"However, another study suggested that UCHL5 stabilizing NFRKB, a chromatin-remodeling protein, may promote GC cell proliferation and metastasis [87]."
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