IndraLab

Statements

Prostaglandin E2-UM inhibits NLRP3. 8 / 8
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"Thus, PGE 2 specifically inhibited the activity of NLRP3 inflammasome."
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"Here we found that PGE 2 decreased NLRP3 inflammasome activation, triggered by aluminum crystals, ATP or nigericin."
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"PGE 2 inhibits NLRP3 inflammasome through EP4 receptor."
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"Using multiple pharmacological and molecular approaches, we have determined that PGE 2 acted specifically through EP4 to decrease NLRP3 inflammasome activation in human primary MDM."
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"This suggests that the proposed PGE 2 -mediated inhibition of NLRP3 by increase in cAMP might be an additional mechanism of ω-3 derived effects."
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"Having found that exogenous PGE 2 inhibits NLRP3 inflammasome activation in human primary MDM, we wondered whether endogenous PGE 2 production might serve as a regulatory autocrine or paracrine mechanism against excessive NLRP3 activation."
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"Here we have found that PGE 2 inhibited NLRP3 inflammasome activation in human primary MDM."
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"Here, we showed that NLRP3 inflammasome activation is inhibited by PGE 2 in human primary monocyte derived macrophages."
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