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USP14 activates Proteasome. 18 / 19
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"Accordingly , the inhibition of USP14 could improve the proteasome degradation activity [ 14 ] ."
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"Loss of Ubp6 function, for example, increases aneuploidy tolerance in yeast, presumably due to an elevated proteasome capacity for turning over higher protein levels, and pharmacological inhibition of Usp14 in human cells has been shown to stimulate proteasome activity XREF_BIBR - XREF_BIBR."
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"Recently, a small chemical compound (IU1) capable of inhibiting USP14 deubiquitination was shown to enhance proteasome mediated degradation of some substrates, including several proteins associated with neural degenerative diseases [XREF_BIBR]."
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"These USP14 specific aptamers effectively inhibited deubiquitinating activity and enhanced proteasome activity in vitro."
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"In contrast, siRNA of either UCHL5 or USP14 alone did not affect proteasome composition but did increase the rate of proteasome activity, supporting previous studies."
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"Consistent with the effects of USP14 upon the proteasome, these USP14 aptamers enhanced proteasome activity, and facilitated the degradation of Alzheimer's disease (AD)-implicated tau proteins."
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"Depletion of USP14 alone enhances proteasome activity, whereas co-depletion with UCHL5 inhibits the proteasome, indicating some cross-dependence for these DUBs during protein degradation."
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"The deubiquitinating enzyme ubiquitin specific peptidase 14 (USP14) has been shown to modulate both proteasome activity and autophagy."
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"Usp14 and Ubp6 can enhance the ATPase activity of the proteasome and partially open the CP gate [52,56-58]."
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"The inhibition of UCHL5 and USP14 deubiquitinase activity by WP1130 is expected to block the function of the proteasome in tumor tissue cells, but this still needs to be tested (D'Arcy et al., 2015)."
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"UBL domain of Usp14 and other proteins stimulates proteasome activities and protein degradation in cells."
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"These results strongly suggest that the USP14 mediated proteasome activity regulation may be directly related to various human diseases including cancer."
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"Conversely, USP14 might also activate proteolysis by degrading ubiquitin chains on target proteins and thereby enhance gate opening of the 20S proteasome."
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"Therefore, USP14 aptamers could be used to understand molecular mechanisms of USP14 activity and Ub homeostasis in cells.How to cite this article: Lee, J. H. et al. Facilitated Tau Degradation by USP14 Aptamers via Enhanced Proteasome Activity."
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"In a more targeted approach, an active-site ubiquitin probe (HA-Ub-VMS) has been used to demonstrate that USP14/UCHL5 inhibition by a small molecule (b-AP15) inhibits the 19S proteasome in a reconstituted biochemical assay."
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"A series of studies have demonstrated that Ubp6 and USP14 enhances the ATPase activity of proteasome and opens the 20S gate upon treatment with ubiquitin, ubiquitin protein conjugate or active site directed probes, such as ubiquitin aldehyde (Ubal) or ubiquitin vinyl sulfone (UbVS) (XREF_FIG A, right bottom panel) [XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR]."
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"Remarkably, Akt dependent phosphorylation of USP14 elevates the catalytic activity of proteasome associated USP14 beyond this level."
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"These data suggested that huaier extract induces proteasome mediated degradation of AR-FL and AR-V7 by downregulation USP14."
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