IndraLab

Statements

CALM activates KCNQ2. 9 / 9
| 1 8
eidos
"Meanwhile , CaM knockdown reduced the KCNQ2 current and increased neuronal activity ."
30213136
reach
"The Naoto Hoshi’s group demonstrated that the phosphorylation of CaM, mediated by casein kinase 2, enhanced the binding with Kv7.2, induced resistance to PIP depletion, thus, leading to an augmentation on Kv7.2 current amplitude [62]."
30022004
reach
"We demonstrate that phosphorylation of calmodulin by protein kinase CK2 (casein kinase 2) rapidly and reversibly modulated KCNQ2 current."
24627475
reach
"These experiments demonstrate that the tethering of CaM to KCNQ channels is essential for their expression at the AIS.We then tested the possibility that CaM expression could rescue the assembly and t[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
24333508
reach
"Meanwhile, calmodulin knockdown reduced KCNQ2 current and increased neuronal activity, showing that hippocampal neuronal excitability is regulated by expression level of calmodulin protein."
28078031
reach
"Nonetheless, CaM induced a comparable increase of KCNQ2-I340A and KCNQ3-I342A or KCNQ2 and KCNQ3-I 342A currents (138% vs. 118%)."
24333508
reach
"Coexpression of Ca 2+ -insensitive CaM has been reported to moderately increase the ER retention of KCNQ2 by 20% in HEK293T cells XREF_BIBR, XREF_BIBR, suggesting that enrichment of KCNQ channels at the axonal surface may be regulated by Ca 2+ -bound CaM."
25077630
reach
"We show that CaM enhances the heteromeric association of KCNQ2 and KCNQ3-I 342A subunits by binding to their B helices in a calcium dependent manner."
24333508
reach
"Recently, it has been shown by XREF_BIBR that KCNQ2 BNFS causing mutations express alterations in CaM binding and that in some cases CaM overexpression restored normal function of the KCNQ2 and KCNQ3 induced channels."
27307626