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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

ATXN3 activates sub. 2 / 2

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"The ubiquitination of ATXN3, primarily at site K117, activates the DUB function of ATXN3 through a conformational switch, which improves the editing of Ub chains on substrates."

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"Though normal and expanded ATXN3 bind similarly to polyubiquitinated parkin, pathogenic ATXN3 shows increased DUB activity towards polyUb-parkin, promoting its degradation via autophagy."

22133674

Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...