IndraLab

Statements

ATXN3 activates sub. 2 / 2

| 2

reach

"The ubiquitination of ATXN3, primarily at site K117, activates the DUB function of ATXN3 through a conformational switch, which improves the editing of Ub chains on substrates."

30283301

➶

reach

"Though normal and expanded ATXN3 bind similarly to polyubiquitinated parkin, pathogenic ATXN3 shows increased DUB activity towards polyUb-parkin, promoting its degradation via autophagy."

22133674

INDRA sources:

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IndraLab

Statements

ATXN3 activates sub. 2 / 2

INDRA sources:

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