IndraLab

Statements

TANK binds USP10 and ZC3H12A. 5 / 5
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"Genotoxic stress also produced a TANK, MCPIP1, and USP10 complex that effected and enhanced deubiquitination of both TRAF6 (E3 Ubiquitin Protein Ligase) and NEMO, which in turn inhibited NF-kappaB activation."
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"MCPIP1 forms a complex with USP10 and TANK, which mediates the deubiquitination of the TRAF6 K63 chain [76] and inhibits NF-κB activation upon DNA damage [33] ."
35627217
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"Intriguingly, TANK was identified as a MCPIP1-interacting protein in a proteomic screen and we confirmed that TANK forms a complex with MCPIP1 and USP10."
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"Furthermore, we found that the TANK, MCPIP1, and USP10 complex also decreased TRAF6 ubiquitination in cells treated with IL-1beta or LPS."
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"In addition to genotoxic stress, the TANK, MCPIP1, and USP10 complex is also responsible for restraining TRAF6 ubiquitination in cells treated with LPS or IL-1beta."
28626800