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USP6 activates Neoplasms. 22 / 22
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"Lu et al. [6] reported a novel CTNNB1-USP6 fusion in IVF, showing that IVF is a USP6-induced neoplasm and should be included in USP6-rearranged lesions.The most common clinical presentation is a painless, slowly growing mass."
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"[USP6 induced neoplasm and their clinicopathological and genetic advances]."
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"In addition, USP6 could also drive the growth of xenograft tumors through activating Wnt signaling pathway [ 9 ]."
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"We therefore propose a model for the pathogenesis of TRE17-driven tumors in which TRE17 increases CD147 at the cell surface by preventing its lysosomal degradation, which in turn enhances MMP synthesis and matrix degradation, thereby promoting tumor cell invasion."
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"Recurrent USP6 rearrangements, specifically MYH9-USP6 fusion, have been identified in majority of nodular fasciitis cases, which defines primary ABC and nodular fasciitis as the biologic spectrum of U[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Previously, it was believed to occur as a reaction to trauma or as a reactive lesion caused by an underlying vascular event, but in recent years, it has been considered a true neoplasm caused by rearrangement of the ubiquitin-specific peptidase 6 (USP6) gene."
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"For example, Madan et al. showed that the USP6 oncogene promotes Wnt signaling by deubiquitylating Frizzleds and inhibition of Wnt signaling significantly decreased the growth of USP6-driven xenograft tumors [20]."
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"However, a USP6 gene rearrangement study is of help in differentiating them because ABC is a true neoplasm-inducing USP6 gene rearrangement."
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"USP6 functions as a deubiquitinase and a designated oncogene, responsible for various cancers and sarcomas progression.USP6 modulates key pathways like NF-κB, JAK-STAT and Wnt/β-catenin driving tumor progression and inflammation.USP6 is implicated in a variety of cell biological processes, including cell cycle regulation, proliferation, invasion, migration, and DNA damage repair."
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"To further determine the role of Wnt signaling in USP6-mediated tumor growth, they tested USP6/NIH 3T3 cells with DKK1, a secreted protein that inhibits Fzd receptor activation."
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"Xenografting CRISPR cells into immunodeficient mice indicated a crucial role for JAK1 and STAT3 in USP6-induced tumor development."
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"Depleting JAK1 significantly knocks down the mass of USP6-induced tumors, whether completely or partially.Liu and Wen et al. found that USP6 levels were elevated in bone marrow aspiration specimens from CML patients, which was associated with a poor prognosis."
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"Mice allografts stably expressing USP6 and its vector demonstrate that USP6-mediated NF-κB upregulation promotes tumorigenesis and tumor vascularization (60)."
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"Intra-articular nodular fasciitis and aneurysmal bone cyst seem to belong to the same biological spectrum defined as USP6-induced tumors according to the report [8]."
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"The findings of this case suggest that these two tumors reside in the same biologic spectrum defined as USP6-induced tumors."
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"Since the discovery of USP6 gene rearrangements in aneurysmal bone cysts nearly 20 years ago, we have come to recognize that there is a family of USP6-driven mesenchymal neoplasms with overlapping clinical, morphologic, and imaging features."
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"The purpose of this article is to review the imaging characteristics of the spectrum of USP6-driven neoplasms, highlight key features that allow distinction from malignant bone or soft tissue lesions, and discuss the role of imaging and molecular analysis in diagnosis."
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"Although this fusion is expected to lead to the high expression of USP6 or be the main mechanism of USP6 gene-mediated tumor pathogenesis, the high percentage of COL1A1 as a fusion partner in these tumor subtypes still likely has a potential association with the osteoid formation on the histology, but further research is needed."
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"Recently, Oliveira and Chou suggested that aneurismal bone cysts and nodular fasciitis reside in the same biologic spectrum as USP6-induced tumors [9]."
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"Although the molecular diagnosis was not performed, the findings of present case suggest that these two tumors reside in the same biologic spectrum defined as USP6-induced tumors."
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"USP6-induced neoplasms are almost universally benign and cured by local excision."
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"All of these findings suggest that JAK-STAT3 is activated in neoplasms with USP6 translocation and that focusing on this pathway could be a useful strategy for reducing the growth of tumors caused by overexpression of USP6 [81]."
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