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CTNNB1 binds KCNQ1. 21 / 21
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"We shall later see that homomeric KCNQ1 can associate with β-catenin (encoded by CTNNB1 gene) in CRC cells to prevent its nuclear translocation and impede cell proliferation and de-differentiation into a mesenchymal phenotype."
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"Recent studies have shown convergence between KCNQ1 and β-catenin regulatory pathways in CRC and the molecular mechanisms regulating KCNQ1:β-catenin interactions and their effects on CRC cell differentiation, proliferation, and invasion ( xref )."
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"KCNQ1 (potassium channel) can interact with β-catenin to affect its subcellular distribution."
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"The interaction of KCNQ1 with β-catenin reduces Wnt/β-catenin signaling, which consequently blocks the expression of its downstream targets, such as MMP7, CCND1, and c-Myc."
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"This might be expected since membrane transport is critical to the homeostatic function of luminal epithelial cells, but so far, this has not been extensively explored outside of colorectal epithelium, where there is a reported interaction between KCNQ1 and β-catenin ( xref )."
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"Mechanistically, KCNQ1 can interact with beta-catenin to affect its subcellular distribution and subsequently reduce the activity of Wnt and beta-catenin signaling, which further blocks the expression of its downstream targets [XREF_BIBR]."
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"KCNQ1 channels modulate Wnt signalling in a wide number of GI cancers [ xref ] and there is strong evidence for bidirectional interaction between KCNQ1 and β-catenin in normal healthy colon and in colon cancer cells [ xref ]."
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"The association of KCNQ1 with β-catenin at the cell membrane is essential to preserve a well-differentiated epithelial phenotype by maintaining a stable KCNQ1: β-catenin:E-cadherin complex at adherens junctions and preventing epithelial–mesenchymal transition [ xref ]."
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"KCNQ1 channels modulate Wnt signalling in a wide number of GI cancers [208] and there is strong evidence for bidirectional interaction between KCNQ1 and β-catenin in normal healthy colon and in colon cancer cells [207]."
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"Bidirectional KCNQ1 : beta-catenin interaction drives colorectal cancer cell differentiation."
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"KCNQ1 (potassium channel) can interact with beta-catenin to affect its subcellular distribution."
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"We investigated the molecular mechanisms regulating KCNQ1:β-catenin bidirectional interactions and their effects on CRC differentiation, proliferation, and invasion."
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"Mechanistically, KCNQ1 can interact with β-catenin to affect its subcellular distribution and subsequently reduce the activity of Wnt/β-catenin signaling, which further blocks the expression of its downstream targets [ xref ]."
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"Recently, Rapetti-Mauss et al. have demonstrated that bidirectional interaction between KCNQ1 and β-catenin drives colorectal cancer cell differentiation [ 24 ]."
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"Proximity ligation assay was conducted to investigate the interactions between KCNQ1 and β-catenin according to manufacturer's protocol (Olink Bioscience, DUO92007)."
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"Likewise, KCNQ1 protein can also be detected in the immunoprecipitates of β-catenin ( Fig. 3 D), suggesting the interaction between KCNQ1 and β-catenin."
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"Moreover, the proximity ligation assay was conducted to visualize the interaction of KCNQ1 with β-catenin based on a co-localization of target proteins in close proximity (30–40 nm)."
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"In this study, we confirmed the interaction between KCNQ1 and β-catenin in HCC cells by co-immunoprecipitation and proximity ligation assay."
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"As a result, KCNQ1 did interact with β-catenin in KCNQ1-overexpressing Huh7 and LM3 cells ( Fig. 3 E)."
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"Samples were subjected to western blotting analysis using anti-KCNQ1 (SAB2108683, Sigma) and anti-β-catenin (#8480, Cell Signaling Technology, Shanghai, China) antibodies and stained using the ECL sys[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Likewise, KCNQ1 protein can also be detected in the immunoprecipitates of β-catenin ( Fig. 3 D), suggesting the interaction between KCNQ1 and β-catenin."
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