IndraLab

Statements

CTNNB1 binds KCNQ1. 12 / 12
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"Mechanistically, KCNQ1 can interact with beta-catenin to affect its subcellular distribution and subsequently reduce the activity of Wnt and beta-catenin signaling, which further blocks the expression of its downstream targets, including c-Myc, MMP7, and CCND1."
30144972
sparser
"We investigated the molecular mechanisms regulating KCNQ1:β-catenin bidirectional interactions and their effects on CRC differentiation, proliferation, and invasion."
28373572
sparser
"Recent studies have shown convergence between KCNQ1 and β-catenin regulatory pathways in CRC and the molecular mechanisms regulating KCNQ1:β-catenin interactions and their effects on CRC cell differentiation, proliferation, and invasion ( xref )."
33363037
reach
"KCNQ1 (potassium channel) can interact with beta-catenin to affect its subcellular distribution."
32850327
sparser
"Mechanistically, KCNQ1 can interact with β-catenin to affect its subcellular distribution and subsequently reduce the activity of Wnt/β-catenin signaling, which further blocks the expression of its downstream targets [ xref ]."
33802791
reach
"Mechanistically, KCNQ1 can interact with beta-catenin to affect its subcellular distribution and subsequently reduce the activity of Wnt and beta-catenin signaling, which further blocks the expression of its downstream targets [XREF_BIBR]."
33802791
sparser
"The interaction of KCNQ1 with β-catenin reduces Wnt/β-catenin signaling, which consequently blocks the expression of its downstream targets, such as MMP7, CCND1, and c-Myc."
32850327
sparser
"KCNQ1 (potassium channel) can interact with β-catenin to affect its subcellular distribution."
32850327
sparser
"We shall later see that homomeric KCNQ1 can associate with β-catenin (encoded by CTNNB1 gene) in CRC cells to prevent its nuclear translocation and impede cell proliferation and de-differentiation into a mesenchymal phenotype."
33363037
sparser
"Mechanistically, KCNQ1 can interact with β-catenin to affect its subcellular distribution and subsequently reduce the activity of Wnt/β-catenin signaling, which further blocks the expression of its downstream targets, including c-Myc, MMP7, and CCND1."
30144972
reach
"Bidirectional KCNQ1 : beta-catenin interaction drives colorectal cancer cell differentiation."
28373572
reach
"The present study explored the functional interaction of beta-catenin and KCNE1 and KCNQ1, the K+ channel complex underlying the slowly activating outwardly rectifying K+ current."
22583083