IndraLab

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COPS6 activates Neoplasm Metastasis. 12 / 12
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"CSN6 inhibition suppresses pancreatic adenocarcinoma metastasis via destabilizing the c-Fos protein."
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"Re-expression of FOXA1 rescued the decreased invasion and metastasis caused by CSN6 knockdown, whereas inhibition of FOXA1 alleviated the pro metastasis effect induced by CSN6 overexpression."
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"CSN6 has the capability to promote the formation of spheres enriched in CSCs, suggesting that CSN6 overexpression may promote distant metastasis and confer resistance after chemotherapy."
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"Furthermore, we identified that CSN6 enhancement leads to Snail1 stabilization and promotes metastasis of breast cancer cells through inhibiting Snail1 ubiquitination."
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"Furthermore, in CSN6-knockdown melanoma cells, UBR5 knockdown abrogated the effects caused by CSN6 silencing, suggesting that CSN6 activates the UBR5 and CDK9 pathway to promote melanoma cell proliferation and metastasis."
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"CSN6 promotes melanoma proliferation and metastasis by controlling the UBR5-mediated ubiquitination and degradation of CDK9 As a critical subunit of the constitutive photomorphogenesis 9 ( COP9 ) signalosome ( CSN ) , CSN6 is upregulated in some human cancers and plays critical roles in tumorigenesis and progression , but its biological functions and molecular mechanisms in melanoma remain unknown ."
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"Our study reveals that CSN6 promotes the migration and metastasis of breast cancer cells, indicating that CSN6 functions as an oncogene in breast cancer cells."
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"Moreover, we demonstrated that CSN6 promoted invasion and metastasis through regulating forkhead box protein A1 (FOXA1) in PAAD cells."
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"CSN6 promotes tumor metastasis via up-regulating snail1 in xenograft model."
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"CSN6 promotes melanoma proliferation and metastasis by controlling the UBR5-mediated ubiquitination and degradation of CDK9 ."
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"The results demonstrated that CSN6 promoted tumor metastasis in vivo and up-regulated the protein level of Snail1 , which was consistent with the results mentioned in vitro experiments ."
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"CSN6 promotes tumor metastasis via up-regulating snail1 in xenograft model To identify the role of CSN6 in the metastatic potency of breast cancer cells in vivo , lentiviruses packed with CSN6-NC or CSN6 overexpression vectors were transfected into MDA-MB-231 cell lines , and the fluorescence intensity was detected by Olympus light microscope ( Figure 4A ) ."
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