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COPS6 activates Neoplasm Metastasis. 20 / 20
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"CSN6 promotes tumor metastasis via up-regulating snail1 in xenograft model."
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"Our study reveals that CSN6 promotes the migration and metastasis of breast cancer cells, indicating that CSN6 functions as an oncogene in breast cancer cells."
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"Importantly, inhibition of CSN6 decreased the metastasis of PAAD to liver."
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"CSN6 promotes tumor metastasis via up-regulating snail1 in xenograft model To identify the role of CSN6 in the metastatic potency of breast cancer cells in vivo , lentiviruses packed with CSN6-NC or CSN6 overexpression vectors were transfected into MDA-MB-231 cell lines , and the fluorescence intensity was detected by Olympus light microscope ( Figure 4A ) ."
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"The results demonstrated that CSN6 promoted tumor metastasis in vivo and up-regulated the protein level of Snail1 , which was consistent with the results mentioned in vitro experiments ."
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"Our data demonstrated that CSN6 could promote metastasis of CC cells via CTSL."
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"Furthermore, in CSN6-knockdown melanoma cells, UBR5 knockdown abrogated the effects caused by CSN6 silencing, suggesting that CSN6 activates the UBR5 and CDK9 pathway to promote melanoma cell proliferation and metastasis."
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"CSN6 has the capability to promote the formation of spheres enriched in CSCs, suggesting that CSN6 overexpression may promote distant metastasis and confer resistance after chemotherapy."
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"On the basis of our mechanistic studies, we developed a model of CSN6 modulating CTSL stability and metastasis (Fig. 10)."
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"Therefore, understanding the relationship between autophagy and CTSL is critical to develop treating strategy for CC patients.In this study, we verified CSN6 and CTSL levels in CC tissues and explored the involvement of CTSL in CSN6-mediated metastasis."
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"Furthermore, the promoting effects of upregulated ALDOA on CRC cell proliferation and metastasis were inhibited by COPS6 depletion, demonstrating COPS6 was required for ALDOA in mediating CRC progress."
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"CSN6 promotes melanoma proliferation and metastasis by controlling the UBR5-mediated ubiquitination and degradation of CDK9 As a critical subunit of the constitutive photomorphogenesis 9 ( COP9 ) signalosome ( CSN ) , CSN6 is upregulated in some human cancers and plays critical roles in tumorigenesis and progression , but its biological functions and molecular mechanisms in melanoma remain unknown ."
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"As shown in Fig. 3 , overexpression of FOXA1 could enhance CFPAC-1 cells’ invasion and metastasis abilities, and the re-expression of FOXA1 could attenuate the decrease of invasion and metastasis indu[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Our results showed that knocking down FOXA1 inhibited the increase of invasion and metastasis abilities stimulated by overexpression of CSN6 ( Fig. 3 g-j)."
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"These results suggested that CSN6-mediated high expression of FOXA1 had an important role in metastasis of PAAD.Next, we sought to figure out the molecular mechanism of which CSN6 regulate the express[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Furthermore, we identified that CSN6 enhancement leads to Snail1 stabilization and promotes metastasis of breast cancer cells through inhibiting Snail1 ubiquitination."
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"In addition, studies shown that CSN6 has the function of deubiquitinase and promoted tumorigenesis, proliferation, metastasis and EMT by inhibiting substrates degradation [ 14–16 ]."
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"CSN6 promotes metastasis by increasing CTSL expression in CC cells."
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"In vivo experiment showed that the metastasis of liver was significantly suppressed in CSN6-silencing group, this result confirmed that inhibition of CSN6 repressed the metastasis of PAAD cells ( Fig.[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Our results demonstrated that CSN6 could promote metastasis of CC cells via CTSL."
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