IndraLab

Statements

USP1 binds FANCD2. 20 / 20
3 1 | 7 9
hprd
No evidence text available
15694335
biogrid
No evidence text available
15694335
sparser
"As USP1's interaction with FANCD2 is dependent on the N-terminus, we wanted to determine whether this is specific for hs FANCD2, so we similarly assayed interactions of hs FANCI and hs PCNA."
30456385
reach
"Further experiments showed that USP1 physically interacts with FANCD2 and that the two proteins colocalize in chromatin after DNA damage XREF_BIBR."
19327579
sparser
"Furthermore, USP1 physically associates with FANCD2, and the proteins colocalize in chromatin after DNA damage."
15694335
biogrid
No evidence text available
18082604
reach
"Furthermore, USP1 physically associates with FANCD2, and the proteins colocalize in chromatin after DNA damage."
15694335
reach
"As USP1's interaction with FANCD2 is dependent on the N-terminus, we wanted to determine whether this is specific for hsFANCD2, so we similarly assayed interactions of hsFANCI and hsPCNA."
30456385
biogrid
No evidence text available
15694335
sparser
"In addition, USP1 Δ1Δ2 -R22A only partially interacts with hs FANCD2, and USP1 Δ1Δ2 -R22K does not weaken the substrate interaction—both results are consistent with the hs FANCD2-Ub deubiquitination assays ( xref and xref )."
30456385
sparser
"Together, these data indicate that the N-terminus of USP1 directly interacts with FANCD2."
30456385
sparser
"It is possible that a more specific inhibitor could block FANCD2–USP1 interaction, such as the N-terminus, and may provide a more specific therapy."
30456385
sparser
"Further experiments showed that USP1 physically interacts with FANCD2 and that the two proteins colocalize in chromatin after DNA damage xref ."
19327579
sparser
"The N-terminus of USP1 binds specifically to FANCD2, and not FANCI or PCNA."
30456385
reach
"XREF_BIBR, XREF_BIBR USP1 binds to FANCD2 and the inhibition of USP1 leads to the accumulation of monoubiquitylated FANCD2 and mitomycin C hypersensitivity, suggesting that failure to deubiquitylate FANCD2, like impaired ubiquitylation, inhibits its function in repairing DNA interstrand cross-links."
21113239
reach
"Like mono-ubiquitylated FANCD2, USP1 levels are regulated during the cell cycle, and USP1 has also been shown to interact directly with FANCD2 and to co-localise with chromatin."
23712866
reach
"This inactivation of the pathway occurs when USP1, a de-ubiquitinating enzyme, associates with FANCD2 within the nuclear foci and removes the monoubiquitin moiety [XREF_BIBR]."
23333482
reach
"UAF1 SLD2 binds directly to a SIM in FANCI, bridging the interaction between USP1 and UAF1 and FANCD2 and FANCI."
26927199
sparser
"This interaction between USP1 and FANCD2 ties the FA pathway to the TLS pathway as USP1 has since been found to also be the DUB for PCNA."
19327579
sparser
"These data indicate the USP1 binding to hs FANCD2, which is almost completely dependent on the N-terminus of USP1."
30456385