IndraLab

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RPS6KB1-S6K phosphorylates IRS1 on serine. 3 / 3
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"For this reason, we included the same β-actin representative blot in the figures for mTOR and p70 S6K.Similarly, p70 S6K, the downstream effector of mTOR, is implicated in the serine phosphorylation of IRS-1, leading to impaired insulin signaling and insulin resistance [41]."
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"Additionally, p70 S6K, the downstream effector of mTOR, has been shown to cause serine phosphorylation of IRS-1, resulting in impaired insulin signaling and insulin resistance [XREF_BIBR]."
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"A number of works showed that p70 S6K, which is downstream of mTOR, could phosphorylate serine residues on IRS-1 to result in proteasomal degradation."
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