IndraLab

Statements

CYLD inhibits Fibrin. 6 / 6
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"CYLD impairs production of fibrin in Listeria infection in mice by inhibiting NF-kB-mediated activation of IL-6 production and IL-6 's activation of the STAT3 pathway that leads to fibrosis [XREF_BIBR]."
25342597
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"Before, we have shown that CYLD inhibits protective fibrin production by hepatocytes in listeriosis."
26834734
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"In addition, in vivo Cyld siRNA treatment increased STAT3 phosphorylation, fibrin production, pathogen control and survival of Lm infected WT mice illustrating that therapeutic inhibition of CYLD augments the protective NF-kappaB/IL-6/STAT3 pathway and fibrin production."
23825949
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"In WT mice, IL-6 neutralization only slightly reduced pSTAT3 without affecting fibrin (XREF_FIG) indicating that IL-6 induced pSTAT3 is strongly regulated by CYLD, which limits STAT3 activity and STAT3 dependent fibrin production."
23825949
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"CYLD reduced activation of p65, JAK2, STAT3, and p38 MAPK as well as fibrin production in livers of Listeria infected WT mice."
23825949
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"The observation that siRNA mediated inhibition of CYLD in WT mice increased hepatic p-STAT3 and fibrin levels, diminished hemorrhage and significantly increased survival indicates that inhibition of CYLD might be a therapeutic option in severe listeriosis and potentially other infectious diseases including acute lung injury induced by S. pneumoniae XREF_BIBR."
23825949