IndraLab

Statements

MTOR phosphorylates RPS6KB1 on T444. 6 / 6
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"Inhibition of mTOR with rapamycin blocked the Thr 389 but not the Thr-421 and Ser-424 phosphorylation of S6K1."
11940578
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"Ethanol inhibition of p70S6K phosphorylation could have been mediated by inhibition of Akt, mTOR, or both, as the multiplex-ELISA detected pTpS421/424 -p70S6K; the T421 and S424 residues on p70S6K are phosphorylated by Akt and mTOR ( xref )."
21790669
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"Furthermore, the knockdown of Mtor by Mtor siRNA reduced insulin- induced phosphorylation of RPS6KB1 Thr 389, RPS6KB1 Thr 421 / Ser 424, RPS6 Ser 235/236 and EIF4EBP1 Thr 37/46 (XREF_FIG)."
23261705
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"P70S6K is phosphorylated by FRAP/mTOR downstream of Akt at Thr389 and at Thr421/Ser42, downstream of the Ras-Raf-MEK-ERK pathway."
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"PHD3 knockdown also increased the phosphorylation of JNK at Thr 183 and Tyr 185 under basal and TNF-α-stimulated conditions (Fig.  xref ) but reduced mTOR complex 1-dependent phosphorylation of p70 S6 kinase at Thr 389 , Thr 421 , and Ser 424 (ref. xref ) under insulin stimulation (Supplementary Fig.  xref ), consistent with impaired insulin signalling."
30250231
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"In a previous study, we showed that mTOR could phosphorylate p70S6K at Thr 421/Ser 424, a specific site of ERK and inversely, ERK could phosphorylate p70S6K at Thr 389 controlled by mTOR signalling (L[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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