IndraLab

Statements

USP11 activates autophagy. 13 / 13
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"In our study, we found that USP11 could induce resistance to chemotherapy by activating autophagy."
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"Collectively , these findings suggest that USP11 could promote autophagy via AMPK / Akt / mTOR signaling pathway dependent on VCP ."
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"The above experimental results have confirmed that USP11 could not only mediate the resistance to 5-Fu, but also induce autophagy in colorectal cancer cells."
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"USP11 promotes autophagy through AMPK/Akt/mTOR signaling pathway in a VCP dependent manner."
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"In conclusion, this study shows that ferroptosis is closely associated with SCIRI, and that USP11 plays a key role in regulating ferroptosis and additionally identifies USP11-mediated autophagy-dependent ferroptosis as a promising target for the treatment of SCIRI."
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"Our previous experiments have confirmed that USP11 can promote autophagy in colorectal cancer cells, however, the underlying mechanisms were still unknown."
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"USP11 promotes 5-Fu resistance through inducing autophagy dependent on VCP The above experimental results have confirmed that USP11 could not only mediate the resistance to 5-Fu , but also induce autophagy in colorectal cancer cells ."
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"A series of in vitro and in vivo experiments revealed that USP11 promoted autophagy through AMPK/Akt/mTOR pathway via stabilizing valosin containing protein (VCP)."
33758608
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"USP11 promotes autophagy through AMPK / Akt / mTOR signaling pathway in a VCP-dependent manner Our previous experiments have confirmed that USP11 can promote autophagy in colorectal cancer cells , however , the underlying mechanisms were still unknown ."
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"Taken together these data, we hypothesized that USP11 might mediate resistance to 5-Fu by inducing autophagy in colorectal cancer cells and verified the hypothesis in follow-up experiments."
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"Our study investigated the role of ubiquitin specific protease 11 (USP11) in CRC chemotherapy and found that USP11 could induce resistance to 5-fluorouracil by activating autophagy."
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"Thus, we hypothesized that USP11 could promote resistance to 5-Fu in colorectal cancer by inducing autophagy."
33758608
eidos
"A series of in vitro and in vivo experiments revealed that USP11 promoted autophagy through AMPK / Akt / mTOR pathway via stabilizing valosin-containing protein ( VCP ) ."
33758608