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USP11 activates autophagy. 18 / 18
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"USP11 promotes 5-Fu resistance through inducing autophagy dependent on VCP The above experimental results have confirmed that USP11 could not only mediate the resistance to 5-Fu , but also induce autophagy in colorectal cancer cells ."
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"Thus, we hypothesized that USP11 could promote resistance to 5-Fu in colorectal cancer by inducing autophagy."
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"The above experimental results have confirmed that USP11 could not only mediate the resistance to 5-Fu, but also induce autophagy in colorectal cancer cells."
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"A series of in vitro and in vivo experiments revealed that USP11 promoted autophagy through AMPK / Akt / mTOR pathway via stabilizing valosin-containing protein ( VCP ) ."
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"Furthermore, the deubiquitinating enzyme USP11 promotes autophagy-dependent ferroptosis by stabilizing BECN1, leading to ferroptosis-mediated spinal cord ischemia-reperfusion injury [163]."
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"Ubiquitin-specific protease 11 (USP11) was found to induce resistance to 5-FU by inducing autophagy through AMPK/AKT/mTOR pathway in CRC cell lines (188)."
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"USP11 can induce resistance to 5-FU in CRC by activating autophagy via stabilizing VCP[67]."
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"This study investigates the role of ubiquitin-specific protease 11 (USP11) in modulating Forkhead box protein O1 (FOXO1) to promote autophagy and alleviate oxidative stress in lung epithelial cells, which could provide novel insights into ALI therapeutic strategies."
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"Collectively , these findings suggest that USP11 could promote autophagy via AMPK / Akt / mTOR signaling pathway dependent on VCP ."
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"E2F1/USP11 modulates autophagy by regulating the ERK/mTOR pathway, leading to HCC cell proliferation and metastasis."
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"Our study investigated the role of ubiquitin specific protease 11 (USP11) in CRC chemotherapy and found that USP11 could induce resistance to 5-fluorouracil by activating autophagy."
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"A series of in vitro and in vivo experiments revealed that USP11 promoted autophagy through AMPK/Akt/mTOR pathway via stabilizing valosin containing protein (VCP)."
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"Taken together these data, we hypothesized that USP11 might mediate resistance to 5-Fu by inducing autophagy in colorectal cancer cells and verified the hypothesis in follow-up experiments."
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"In conclusion, this study shows that ferroptosis is closely associated with SCIRI, and that USP11 plays a key role in regulating ferroptosis and additionally identifies USP11-mediated autophagy-dependent ferroptosis as a promising target for the treatment of SCIRI."
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"In our study, we found that USP11 could induce resistance to chemotherapy by activating autophagy."
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"USP11 promotes autophagy through AMPK / Akt / mTOR signaling pathway in a VCP-dependent manner Our previous experiments have confirmed that USP11 can promote autophagy in colorectal cancer cells , however , the underlying mechanisms were still unknown ."
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"USP11 promotes autophagy through AMPK/Akt/mTOR signaling pathway in a VCP dependent manner."
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"Our previous experiments have confirmed that USP11 can promote autophagy in colorectal cancer cells, however, the underlying mechanisms were still unknown."
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