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Reactive oxygen species inhibits NFKB1. 4 / 4
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"Consistent with the premise that oxidative stress increases in the aging brain [XREF_BIBR], that ROS impairs NF-kappaB p50 function in microglia [XREF_BIBR], and that aging in peripheral tissues is associated with a loss of NF-kappaB p50 function [XREF_BIBR, XREF_BIBR], we found that 9-month-old mice exhibited less NF-kappaB p50 DNA binding in the brain when compared to younger 3-week-old mice."
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"Importantly, PBN reduced ROS-inhibited HCQ and HCQ + MAVS-stimulated luciferase reporter activity of IFN-b, ISRE, and NFkB (Fig. 6G )."
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"The ROS scavengers N-acetyl cysteine (NAC) and superoxide dismutase (SOD) mimetic MnTBAP inhibited LPS induced accumulation of nuclear RelB and p50, but had no effects on nuclear RelA, c-Rel and p52 (XREF_FIG and XREF_SUPPLEMENTARY)."
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"We can hypothesize that ROS levels need to be sufficiently decreased to induce NFKB activation."
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