IndraLab

Statements

USP7 increases the amount of ARMC5. 3 / 3
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"Given that silencing of USP7 decreased ARMC5 protein expression and the convinced interaction of USP7 with ARMC5, it is highly likely that USP7 serves as an ARMC5 deubiquitinase."
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"Silencing of USP7 decreased ARMC5 levels, accompanied by increasing ARMC5 polyubiquitination, whereas overexpression of USP7 but not its mutants increased ARMC5 levels and reversed ARMC5 polyubiquitination."
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"Furthermore, USP7 knockdown alone abrogated ARMC5 levels and the reduction of ARMC5 caused by USP7 knockdown could be restored by the proteasome inhibitor MG132, suggesting that USP7 maintain the protein levels of ARMC5 by abrogating its proteasomal degradation."
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