IndraLab

Statements

COPS8 binds COPS5. 21 / 31
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"The best characterized of these intracellular effectors is the COP9-signalosome subunit 5 (CSN5), which is an important determinant of cullin-dependent protein turnover ( xref , xref )."
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"Notably, decreases in CSN8 reduced significantly CSN3, CSN5, and CSN7 but not other 4 CSN subunits (XREF_FIG), suggesting that CSN8 may directly interact CSN3, CSN5 and CSN7 during the formation of CSN holo- and mini-complexes and stabilize them."
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"Although the exact site where exosomal protein sorting is regulated by CSN5-associated COP9 deubiquitin activity is unknown, it is significant that we identified that CSN5-associated with COP9 possess[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"We have shown that deubiquitinase activity of CSN5 is associated with COP9."
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"Also, E2/GPER pathway downregulated PD-L1 through COP9-signalosome subunit 5 degradation, as reported in melanoma and pancreatic ductal adenocarcinoma ( xref , xref )."
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"Also plausible is that a deubiquitin enzyme associated with CSN5 or other subunits of COP9 may initiate the reaction, and CSN5 regulates the activity of its associated deubiquitin enzyme since COP9-as[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Knockout of COP9-signalosome subunit 5 (CSN5) suppresses the deneddylation of cullin and leads to cardiac hypertrophy and heart failure [24,25] ."
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