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Statements

USP10 inhibits hepatic steatosis. 4 / 4
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"31 Recently , a report suggested that USP10 can inhibit hepatic steatosis , insulin resistance , and inflammation through Sirt6 in nonalcoholic fatty liver disease ."
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"In a non-alcoholic fatty liver disease model , USP10 inhibits hepatic steatosis , insulin resistance , and the inflammatory response by interacting with SIRT6 and inhibiting its ubiquitination and degradation ( 6 ) , and USP10 inhibition also abolishes Mirt2 ( long non-coding RNA myocardial infarction associated transcript 2 ) overexpression-induced suppression of glucose production and lipogenesis in hepatocytes ( 7 ) ."
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"It has been demonstrated that USP10 inhibits hepatic steatosis and insulin resistance via Sirt6 , in which Sirt6 represses the transcription levels of SREBP1 / SREBP2 and their target genes [ 114 ] ."
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"For example , USP10 expression is decreased and upregulated in hepatic steatosis models to inhibit hepatic steatosis , insulin resistance , and inflammation [ 7 ] ."
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