IndraLab

Statements

USP37 binds ESR1. 7 / 7
3 | 1 3
sparser
"Further mechanistic study revealed the interaction between USP37 and ERα: USP37 regulated ERα signaling through modulating protein stability instead of gene expression, in which it stabilized ERα protein via inhibiting the K48‐specific polyubiquitination process."
36221793
biogrid
No evidence text available
36221793
biogrid
No evidence text available
36221793
biogrid
No evidence text available
36221793
sparser
"Mechanistically, USP37 interacts with ERα and removes the K48‐linked ubiquitin through its catalytical activity, leading to the stabilization of ERα."
36221793
sparser
"These findings demonstrate that USP37 is an essential regulator of estrogen signaling and that the USP37‐ERα axis is a potential target for breast cancer treatment."
36221793
reach
"Further mechanistic study revealed the interaction between USP37 and ERalpha: USP37 regulated ERalpha signaling through modulating protein stability instead of gene expression, in which it stabilized ERalpha protein via inhibiting the K48-specific polyubiquitination process."
36221793