IndraLab

Statements

HCN1 activates pyraclofos. 3 / 3
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"The neuronal sag and rebound slope, as subthreshold voltage signatures, changed and deteriorated with age (Musial et al., 2018), and trafficking the HCN1 channel to distant dendrites restored abnormal subthreshold voltage signaling."
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"A recent study reports that HCN1 channels localize in the active zone of mature asymmetric synaptic terminals and inhibit synaptic glutamate release by suppressing the activity of low-threshold voltage gated T-type Ca 2+ channels [XREF_BIBR]."
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"Phosphorylation of HCN1 channels by p38 MAPK has been shown to activate HCN channels by shifting their voltage-dependent activation towards depolarized potentials; conversely, application of p38 MAPK inhibitors shifts HCN channel activation in a hyperpolarized direction (Poolos et al., 2006)."
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