IndraLab

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TGFB decreases the amount of IRS1. 11 / 11
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"TGFbeta signaling inhibits expression and phosphorylation of IRS-1 in colon cancer cells."
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"Further studies showed that TGFbeta signaling suppresses expression and phosphorylation of IRS-1 in colon cancer cells."
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"These results demonstrate that TGFbeta suppresses expression and activation of IRS-1 in colon cancer cells."
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"We show for the first time that expression and activation of IRS-1, an IGF-1R adaptor protein, is decreased by TGFbeta and Smad3 signaling."
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"In this model, TGFbeta and Smad3 inhibits IRS-1 expression and activation, which leads to suppression of XIAP and cyclin D1 expression."
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"Further studies are needed to investigate whether TGFbeta and Smad3 regulates Cbl-b expression and/or activity in colon cancer cells and whether Cbl-b is responsible for suppression of IRS-1 expression by TGFbeta and Smad3 signaling."
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"In our study, we show, for the first time, that TGFbeta signaling inhibits IRS-1 expression and activation in colon cancer cells in vitro and in vivo and that upregulated IRS-1 contributes to attenuation of TGFbeta signaling mediated tumor suppressive phenotypes."
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"In addition, TGFbeta treatment decreased the expression and phosphorylation of IRS-1 in CBS-RII cells and the RI inhibitor prevented the inhibitory effect of TGFbeta (XREF_FIG)."
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"This study shows, for the first time, that expression and phosphorylation of IRS-1, an IGF-1R adaptor protein, is decreased by TGFbeta and Smad3 signaling."
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"Our findings further show that TGFbeta and Smad3 inhibits IRS-1 protein expression (Figs XREF_FIG and XREF_FIG) but has little effect on IRS-1 mRNA levels (XREF_FIG), indicating that TGFbeta and Smad3 signaling regulates IRS-1 expression at the post-transcriptional level."
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"Further studies indicate that TGFbeta and Smad3 suppresses expression and phosphorylation of IRS-1."
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